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  4. Recombinant Mouse C-type lectin domain family 6 member A (Clec6a), partial

Recombinant Mouse C-type lectin domain family 6 member A (Clec6a), partial

  • 中文名称：
    Recombinant Mouse C-type lectin domain family 6 member A(Clec6a),partial,Yeast
  • 货号：
    CSB-YP864353MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 6 member A(Clec6a),partial,Yeast
  • 货号：
    CSB-EP864353MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 6 member A(Clec6a),partial,Yeast
  • 货号：
    CSB-EP864353MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 6 member A(Clec6a),partial,Yeast
  • 货号：
    CSB-BP864353MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse C-type lectin domain family 6 member A(Clec6a),partial,Yeast
  • 货号：
    CSB-MP864353MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Clec6a
  • Uniprot No.：
  • 别名：
    Clec6a; Clec4n; Clecsf10; Dectin2C-type lectin domain family 6 member A; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.
  • 基因功能参考文献：
    1. Dectin-2 is a primary factor in activation of NLRP3 inflammasome during Histoplasma capsulatum infection. PMID: 28671985
    2. this report relates the potential of the Dectin-2/Card9-coupled pathway in ocular autoimmunity. Not only does it contribute to understanding of how innate immune receptors orchestrate T cell-mediated autoimmunity, it also reveals a previously unappreciated ability of fungal-derived signals to promote autoimmunity. PMID: 28763100
    3. a glycosylated protein with mannose-related structure is recognized by Dectin-2 in dendritic cells PMID: 28046067
    4. Dectin-2 does not play a major role in in phagocytosis and innate defense by phagocytes against Cryptococcus neoformans spores. PMID: 28282442
    5. activation of CLRs Dectin-2 and Dectin-3 by fungi infections triggers them for ubiquitination and degradation in a Syk-dependent manner. PMID: 27432944
    6. this study shows that in vitro, cytokine production by bone marrow-derived dendritic cells is dependent on dectin-2; in vivo, its deficiency compromises fungal clearance PMID: 27189427
    7. these data indicate that mannosylated O-antigens from several Gram-negative bacteria augment TLR4 responses through interaction with Dectin-2. PMID: 27358401
    8. Dectin-2 leads to an increase in cardiac rupture, impairs wound healing, and aggravates cardiac remodeling after MI through the modulation of Th1 differentiation. PMID: 28193608
    9. this study demonstrates the role of Dectin-2 as an essential trigger of host defense in a murine model of systemic candidiasis PMID: 27046240
    10. Polymorphisms within the NKC modulate malarial pathogenesis and acquired immune responses to infection. PMID: 24691125
    11. Dectin-2 may oppose the Th2 response and IL-4-dependent mucin production in the lungs after infection with C. neoformans, and it may not be required for the production of Th1, Th17, and proinflammatory cytokines or for clearance of this fungal pathogen. PMID: 25422263
    12. our data show a requirement for Dectin-2 in alveolar macrophage induction of cysteinyl leukotrienes and in the initiation of airway inflammation. PMID: 24129160
    13. Dectin-2 contributes to host immunity against mycobacterial infection through the recognition of Mannose-capped lipoarabinomannan. PMID: 25176311
    14. Dectin-2 expressed on CD11b(+) dendritic cells promotes house dust mite-induced Th2 and Th17 cell differentiation and allergic airway inflammation. PMID: 24588637
    15. beta-mannosyl linkages inhibit CAWS arteritis by negatively regulating dectin-2-dependent signaling in spleen and dendritic cells. PMID: 23981001
    16. Dectin-2 regulates monocyte-derived dendritic cell function in the pulmonary microenvironment at Dermatophagoides farinae challenge to promote the local inflammatory response. PMID: 24453247
    17. Compared to their respective homodimers, Dectin-3 and Dectin-2 heterodimers bound alpha-mannans more effectively, leading to potent inflammatory responses against fungal infections. PMID: 23911656
    18. monocytes and neutrophils depend on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation PMID: 23049859
    19. PLCgamma2 deficiency impairs Dectin-2-induced NF-kappaB and MAPK activation in response to fungal infection PMID: 22041900
    20. CARD9 is selectively involved in Dectin-2-induced NF-kappaB activation in response to C. albicans hyphae challenging. PMID: 20538615
    21. Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation PMID: 20493731
    22. Dectin-2 may play a crucial role in the mediation of ultraviolet (UV)-induced immunosuppression; moreover, soluble fusion protein Dec2-reactive T cells appear to represent the regulatory T cells responsible for mediating UV-induced tolerance. PMID: 14500681
    23. UV-B can modulate dectin-2 expression by Langerhans cells in C3H and in ICR mice. PMID: 15876128
    24. Dectin-2 expression is characteristic of monocyte activation and maturation at an inflammatory lesion PMID: 15940672
    25. Dectin-2 mediates allergen-elicited cysteinyl leukotrienes in bone marrow-derived dendritic cells stimulated by extracts of house dust mites Dermatophagoides farinae and D. pteronyssinus and the mold Aspergillus fumigatus. PMID: 19124755
    26. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. PMID: 19703985

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  • 亚细胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 组织特异性：
    Expressed by the XS52 DC (dendritic cell) line (at protein level). Expressed constitutively by the epidermis, and skin resident DC appear to be the major source of this expression. Expressed in the spleen and thymus. Expression was undetectable in non-DC
  • 数据库链接：

    KEGG: mmu:56620

    STRING: 10090.ENSMUSP00000024118

    UniGene: Mm.271782