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  4. Recombinant Mouse CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (St8sia4), partial

Recombinant Mouse CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (St8sia4), partial

  • 中文名称：
    小鼠St8sia4重组蛋白
  • 货号：
    CSB-YP734124MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠St8sia4重组蛋白
  • 货号：
    CSB-EP734124MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠St8sia4重组蛋白
  • 货号：
    CSB-EP734124MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠St8sia4重组蛋白
  • 货号：
    CSB-BP734124MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠St8sia4重组蛋白
  • 货号：
    CSB-MP734124MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    St8sia4
  • Uniprot No.：
  • 别名：
    St8sia4; Pst; Siat8d; CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; EC 2.4.99.-; Alpha-2,8-sialyltransferase 8D; Polysialyltransferase-1; Sialyltransferase 8D; SIAT8-D; Sialyltransferase St8Sia IV; ST8SiaIV
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells.
  • 基因功能参考文献：
    1. Mice deficient for ST8SiaIV have impaired long-term spatial memory in two tasks that critically rely on the hippocampus. PMID: 25596866
    2. NCAM-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM-140 catalyzed by STX, but not by PST, enhanced NCAM-mediated cell migration, but not cell proliferation or motility. PMID: 25885924
    3. ST8SiaIV synthesized polySia selectively on a NRP2 glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans. PMID: 23801331
    4. the negative and positive effects of ST8SiaIV overexpression observed during peripheral nerve regeneration suggest that an optimized time- and differentiation-dependent control of expression in Schwann cells may further improve nerve regeneration PMID: 21840969
    5. ST8Sia4 knockout mice display a decreased motivation in social interaction. This deficit can be partly explained by olfactory deficits and was associated with a clear decrease in PSA-NCAM expression in all brain regions analyzed. PMID: 20659171
    6. This study demonistrated that mice lacking St8siaIV polysialyltransferase have an accelerated onset of remyelination after cuprizone-induced demyelination. PMID: 20833231
    7. In summary, the data suggest that the polysialic acid-neural cell adhesion molecule system is a putative target for the modulation of PMID: 20351597
    8. Focusing on the cerebral cortex, our results indicate that ST8SiaIV is solely responsible for PSA expression in mature interneurons and in most regions of cortical neuropil. PMID: 20206239

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 29 family
  • 组织特异性：
    Strongly expressed in lung, heart and spleen and weakly in brain.
  • 数据库链接：

    KEGG: mmu:20452

    STRING: 10090.ENSMUSP00000043477

    UniGene: Mm.306228