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  4. Recombinant Mouse Calcipressin-1 (Rcan1)

Recombinant Mouse Calcipressin-1 (Rcan1)

  • 中文名称：
    小鼠Rcan1重组蛋白
  • 货号：
    CSB-YP862352MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rcan1重组蛋白
  • 货号：
    CSB-EP862352MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rcan1重组蛋白
  • 货号：
    CSB-EP862352MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rcan1重组蛋白
  • 货号：
    CSB-BP862352MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rcan1重组蛋白
  • 货号：
    CSB-MP862352MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rcan1; Dscr1; Calcipressin-1; Down syndrome critical region protein 1 homolog; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-198
  • 氨基酸序列
    MEEVDLQDLP SATIACHLDP RVFVDGLCRA KFESLFRTYD KDTTFQYFKS FKRVRINFSN PLSAADARLR LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQENEEE EEEMERMKRP KPKIIQTRRP EYTPIHLS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
  • 基因功能参考文献：
    1. Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture. PMID: 30442942
    2. These findings demonstrate a novel regulatory role of RCAN1 in TLR signaling, which differentially regulates MyD88 and TRIF pathways. PMID: 29799862
    3. The expression of DSCR1-4 increased strongly at P16 after OIR. There was no change in messenger RNA (mRNA) expression of DSCR1-1 at P16 after oxygen-induced retinopathy. The increased DSCR1 was mainly located in the RGCs of avascular retina. In addition, DSCR1-4 expression was increased in primary RGCs after hypoxia exposure. PMID: 27734335
    4. The present study demonstrates that RCAN1 deficiency protects against Salmonella intestinal infection by enhancing proinflammatory JNK signaling. PMID: 27449908
    5. DSCR1 as a key protein that couples axon growth. PMID: 27185837
    6. from amongst the myriad of gene expression changes occurring in Type 2 diabetes (T2D) b-cells where we had little knowledge of which changes cause b-cell dysfunction, we applied a trisomy 21 screening approach which linked RCAN1 to b-cell mitochondrial dysfunction in T2D. PMID: 27195491
    7. These results uncover a critical link between calcineurin signalling, impaired neurotrophin trafficking and neurodevelopmental deficits in the peripheral nervous system in Down syndrome. PMID: 26658127
    8. Data suggest that expression of Dscr1 in hippocampus can be regulated by dietary factors; supplementation of maternal diet and offspring diet with fish oil down-regulates Dscr1 in hippocampus of offspring; Dscr1 is a presumed target in Down syndrome. PMID: 25799055
    9. inhibition of the calcineurin-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo PMID: 25100642
    10. PACAP targets RCAN1 to control neuronal differentiation. PMID: 26157140
    11. We also confirmed that overexpression of RCAN1-1L could inhibit the transcriptional activation of an NFAT-dependent promoter in response to PMA and ionomycin by inhibiting Calcineurin activity in HEK293T cells PMID: 25193101
    12. Calcineurin and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion. PMID: 24838101
    13. Data indicate that neuron from Down syndrome candidate region 1 (DSCR1)-transgenic mice were more resistant than wild-type neurons to apoptotic cell death following 24 h of glucose deprivation. PMID: 23144708
    14. A major role for haematopoietic Rcan1 in atherosclerosis and suggest that therapies aimed at inhibiting RCAN1 expression or function might significantly reduce atherosclerosis burden. PMID: 24127415
    15. SCF-mediated activation induced expression of Rcan1 in bone-marrow-derived mast cells. Rcan1 suppresses SCF-induced activation of calcineurin & NF-kappaB, & negatively regulates its own expression via Egr1. PMID: 24218457
    16. dosage of DYRK1A and DSCR1 is critical for proper neurogenesis through NFATc and provide a potential mechanism to explain the neurodevelopmental defects in Down's syndrome PMID: 24352425
    17. Suppression of tumor angiogenesis by an additional copy of Dscr1 contributes to the reduced cancer incidence in individuals with Down syndrome. PMID: 24051307
    18. Rcan1 KO mice displayed reduced anxiety in several tests of unconditioned anxiety and lacked the early anxiogenic response to fluoxetine. PMID: 24155299
    19. Trisomy of Dscr1 suppresses the progression of pancreatic intraepithelial neoplasia-1A (PanIN-1A) to PanIN-1B lesions without affecting the initiation of PanIN lesions mediated by oncogenic Kras(G12D). PMID: 24041692
    20. study identifies a novel role for RCAN1 as a central regulator of inflammation during respiratory tract infection in vivo PMID: 23589609
    21. a new regulatory mechanism of RCAN1 function PMID: 23118980
    22. Increased RCAN1 expression may inhibit calcineurin activity to negatively regulate the amount of vesicle content released as well as impacting vesicle endocytosis and recycling. PMID: 23134420
    23. Our data therefore identifies a novel molecular link between the overexpression of RCAN1 and pancreatic beta-cell dysfunction. PMID: 23011918
    24. data strongly suggest that RCAN1 plays an important role in normal brain development and function and its up-regulation likely contributes to the neural deficits associated with Down syndrome PMID: 22511596
    25. DSCR1 is a novel regulator of FMRP and Fragile X syndrome and Down syndrome may share disturbances in common pathways that regulate dendritic spine morphology and local protein synthesis PMID: 22863780
    26. Data indicate normal diurnal corticosterone production in RCAN1 mutant mice and do not suggest a causal role in either the cognitive or anxiety phenotypes exhibited by RCAN1-knockout mice. PMID: 22546913
    27. In this study we report that Rcan1-4 protein and mRNA levels are increased after brain ischemia/reperfusion injury in mice model. PMID: 22397398
    28. a direct link between Dyrk1A and RCAN1 in the Caln-NFAT signaling and Tau hyperphosphorylation pathways PMID: 21965663
    29. Rcan1 represents a novel contributor in the development of eosinophilia in allergic asthma through regulation of eosinophil progenitor production. PMID: 21741935
    30. Results indicate that aneurysm formation and restenosis share mechanistic elements and identify Rcan1 as a potential therapeutic target for prevention of aneurysm and restenosis progression. PMID: 21930771
    31. TgRCAN1 mice present a marked disruption of the learning process in a visuo-spatial learning task. PMID: 21364922
    32. RCAN1 is involved in macrophage and the overall in vivo immune response, and plays an important role in cell immunity and infectious disease. PMID: 21073546
    33. Profile adaptive pancreatic growth, identify Rcan1 as an important new feedback regulator, and firmly establish that calcineurin-NFAT signaling is required for this response. PMID: 20438729
    34. CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4 PMID: 20371871
    35. DSCR1 overexpression attenuates NFAT transcriptional activity in vascular smooth muscle cells. PMID: 19926569
    36. MCIP1 can facilitate or suppress cardiac calcineurin signaling depending on the nature of the hypertrophic stimulus. PMID: 12515860
    37. Calcipressins modulate the pattern of calcineurin-dependent transcription, and may influence calcineurin activity beyond calcium to integrate a broad array of signals into the cellular response. PMID: 12925851
    38. Data show that Down syndrome critical region 1 expression is dependent on NFATc1 and support a role for DSCR1 in normal cardiac valvuloseptal formation and in the abnormal development of organ systems affected in individuals with Down syndrome. PMID: 14738882
    39. expression of DSCR1 isoforms is elevated and NFAT transcriptional activity is decreased in the developing heart and brain PMID: 15906378
    40. identified a small region of DSCR1 that is a potent inhibitor of calcineurin activity in vitro and in vivo PMID: 16131541
    41. possibly the 1.5-fold increase in dosage of DSCR1 and DYRK1A cooperatively destabilizes a regulatory circuit, leading to reduced NFATc activity and many of the features of Down's syndrome PMID: 16554754
    42. Modulatory calcineurin-interacting proteins serve either a permissive or facilitative function for calcineurin-nuclear factor of activated T cells signaling in vivo [Modulatory calcineurin-interacting protein 1 and 2] PMID: 16648267
    43. Findings highlight the importance of RCAN1 gene dosage in the modulation of cell survival and death pathways and suggest that changes in the amount of RCAN1 could represent an important mechanism for regulating susceptibility to neurodegeneration. PMID: 17341486
    44. DSCR1 gene is a direct transcriptional target of NFATc1 proteins within the endocardium during a critical window of heart valve formation. PMID: 17693409
    45. We thus show for the first time that ligand-induced growth cone collapse can activate both calcineurin- and calpain-mediated pathways concurrently. PMID: 17826176
    46. These studies extend and complement previous studies on RCAN isoforms toward better understanding the role of RCAN1 in brain function and as a potential new target for treating calcineurin-related brain disorders. PMID: 17910944
    47. This study propose a model in which RCAN1 plays a positive role in L-LTP and memory by constraining phosphatase signaling. PMID: 18045910
    48. RCAN1 is a novel ATF6-inducible gene that may also be a novel integrator of growth and ER stress signaling in many other tissues that depend on calcineurin/NFAT signaling for optimal growth and development PMID: 18319259
    49. Targeted deletion of Dscr1 leads to hyperactivated calcineurin and precocious endothelial apoptosis, inhibiting formation of an effective tumor vasculature and suppressing tumorigenesis. PMID: 18455125
    50. Inflammatory mediators such as TNFalpha and IL-1beta can induce DSCR1-4 transcription, which may be associated with the alleviation of inflammatory processes. PMID: 18485347

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  • 蛋白家族：
    RCAN family
  • 组织特异性：
    Highly expressed in heart and skeletal muscle. Also expressed in all other tissues.
  • 数据库链接：

    KEGG: mmu:54720

    STRING: 10090.ENSMUSP00000060394

    UniGene: Mm.265744