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  4. Recombinant Mouse Chloride channel protein ClC-Ka (Clcnka), partial

Recombinant Mouse Chloride channel protein ClC-Ka (Clcnka), partial

  • 中文名称：
    Recombinant Mouse Chloride channel protein ClC-Ka(Clcnka),partial,Yeast
  • 货号：
    CSB-YP892985MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Chloride channel protein ClC-Ka(Clcnka),partial,Yeast
  • 货号：
    CSB-EP892985MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Chloride channel protein ClC-Ka(Clcnka),partial,Yeast
  • 货号：
    CSB-EP892985MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Chloride channel protein ClC-Ka(Clcnka),partial,Yeast
  • 货号：
    CSB-BP892985MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Chloride channel protein ClC-Ka(Clcnka),partial,Yeast
  • 货号：
    CSB-MP892985MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Clcnka
  • Uniprot No.：
  • 别名：
    Clcnka; Clcnk1Chloride channel protein ClC-Ka; Chloride channel Ka; ClC-K1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. May be the basolateral chloride channel mediating net chloride absorption in CTAL cells.
  • 基因功能参考文献：
    1. our study provides in vivo evidence that, in response to a low-potassium diet, ClC-K and barttin play important roles in the activation of the WNK4-SPAK-NCC cascade and blood pressure regulation. PMID: 29326302
    2. molecular substrate of a chloride channel previously detected in the mouse thick ascending limb PMID: 23791703
    3. the major component of Cl(-) transport sensitive to NPPB or pH is mediated by CLC-K1 in the tAL. PMID: 11832425
    4. Gene expression profiling in the collecting tubules of aquaporin-1 and CLC-Nk1 knockout mice. PMID: 15713911
    5. induction of SGK1, CLC-K1 and barttin by high osmolarity and change in intracellular volume in distal renal tubular cells in vivo and in vitro PMID: 18614997

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chloride channel (TC 2.A.49) family, CLCNKA subfamily
  • 组织特异性：
    Specifically expressed in the kidney. All nephron segments expressing BSND also express CLCNK proreins.
  • 数据库链接：

    KEGG: mmu:12733

    STRING: 10090.ENSMUSP00000048520

    UniGene: Mm.167900