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  4. Recombinant Mouse Class A basic helix-loop-helix protein 15 (Bhlha15)

Recombinant Mouse Class A basic helix-loop-helix protein 15 (Bhlha15)

  • 中文名称：
    Recombinant Mouse Class A basic helix-loop-helix protein 15(Bhlha15),Yeast
  • 货号：
    CSB-YP879454MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Class A basic helix-loop-helix protein 15(Bhlha15),Yeast
  • 货号：
    CSB-EP879454MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Class A basic helix-loop-helix protein 15(Bhlha15),Yeast
  • 货号：
    CSB-EP879454MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Class A basic helix-loop-helix protein 15(Bhlha15),Yeast
  • 货号：
    CSB-BP879454MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Class A basic helix-loop-helix protein 15(Bhlha15),Yeast
  • 货号：
    CSB-MP879454MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Bhlha15
  • Uniprot No.：
  • 别名：
    Bhlha15; Bhlhb8; Mist1Class A basic helix-loop-helix protein 15; bHLHa15; Class B basic helix-loop-helix protein 8; bHLHb8; Muscle; intestine and stomach expression 1; MIST-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-197
  • 氨基酸序列
    MKTKNRPPRR RTPMQDTEAT PGEQTPDRPQ SGSGGSELTK GLRSRTARAS GGRGEVSRRR QGSGGRRENS VQRRLESNER ERQRMHKLNN AFQALREVIP HVRADKKLSK IETLTLAKNY IKSLTATILT MSSSRLPGLE APGPAPGPKL YQHYHHQQQQ QQQQQQVAGA MLGVTEDQPQ GHLQRYSTQI HSFREGS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in controlling the transcriptional activity of MyoD, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3'.
  • 基因功能参考文献：
    1. Mist1 induces maturation of mouse fetal hepatoblasts. PMID: 26456005
    2. the transient silencing of Mist1 expression is critical for acinar cells to survive an acute pancreatitis episode. PMID: 26717480
    3. Mist1 expressing gastric stem cells maintain the normal/neoplastic gastric epithelium and are supported by a perivascular stem cell niche. PMID: 26585400
    4. A total of 1,555 and 3,057 differentially expressed genes were identified in the wild type and Mist1 knock-out mice with caerulein-induced pancreatitis. PMID: 25975747
    5. Mist1 deficiency predicts the molecular response to experimental pancreatitis. PMID: 24465395
    6. Chromatin immunopreciptation indicated that the loss of Fgf21 in the Mist1(-/-) pancreas is due, in part, to epigenetic silencing. PMID: 24549397
    7. Activation of protein kinase Cdelta leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1. PMID: 22374815
    8. The exocrine pancreas of adult mice can be remodeled by re-expression of the transcription factor MIST1. MIST1 regulates acinar cell maturation and might be used to repair damaged pancreata in patients with pancreatic disorders. PMID: 22510200
    9. findings suggest that an absence of MIST1 increases the sensitivity to ethanol that correlated with decreased activity of the unfolded protein response PMID: 22216129
    10. MIST1 is enriched upon plasma cell differentiation. PMID: 21098683
    11. XBP1 controls the transcriptional regulation of zymogenic cell structural development; it expands the lamellar rough endoplasmic reticulum and induces MIST1 expression to regulate formation of large granules PMID: 20816838
    12. Atp2c2 transcription is regulated by MIST1 PMID: 20599950
    13. MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D. PMID: 20038531
    14. Mist1 functions as a positive regulator of Cx32 gene expression and, sustans acinar cell gap junctions and intercellular communication pathways PMID: 12829745
    15. Mist1 is necessary for complete differentiation and maturation of serous exocrine cells through the combined regulation of several exocrine specific genes. PMID: 15003629
    16. Results suggest that Mist1 is a key transcriptional regulator of exocrine pancreatic cells and that in the absence of functional Mist1, acinar cells do not maintain their normal identity. PMID: 15024058
    17. Mist1 is critical to normal organelle localization in exocrine cells PMID: 15665001
    18. Mist1 within the hierarchy of known helix-loop-helix/basic helix-loop-helix proteins that control mammary epithelial cell development PMID: 16645041
    19. The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. PMID: 17164426
    20. Mist1 knock out islets have increased resistance to strepttozotocin,likely due to a decreased accumulation of Glut-2 PMID: 17196162
    21. This study identified BHLHB8 as a regulator in establishing and stabilizing the secreting epithelial cells of the seminal vesicle. PMID: 17901072
    22. Spasmolytic polypeptide/trefoil factor family 2 (TFF2)-expressing metaplasia (SPEM)was immunoreactive for TFF2, Mist1 and intrinsic factor, suggesting that SPEM derived from transdifferentiation of chief cells. PMID: 18242217
    23. Mist1 has a dual role in the development of the exocrine pancreas: controlling cell proliferation and promoting terminal differentiation. PMID: 18762186

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in pancreatic tissue only in acinar cells. There is a complete absence of expression in intra- or interlobular pancreatic ducts and in all islet cells.
  • 数据库链接：

    KEGG: mmu:17341

    UniGene: Mm.386767