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  4. Recombinant Mouse Coagulation factor V (F5), partial

Recombinant Mouse Coagulation factor V (F5), partial

  • 货号：
    CSB-YP007929MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007929MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007929MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007929MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007929MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    F5Coagulation factor V; Activated protein C cofactor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.
  • 基因功能参考文献：
    1. Mice with the FVL mutation do not have increased spermatogenesis as compared to wildtype mice. PMID: 28927238
    2. Platelet-derived FV is a critical mediator of arterial thrombosis that involves platelet activation. PMID: 28673898
    3. Platelet-derived FV contributes to the control of angiogenesis and is likely associated with thrombin generation in hind limb ischemia model. PMID: 27237401
    4. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin. PMID: 21795745
    5. The FVL mutation does not influence coagulation activation, lung inflammation or survival in lethal influenza A. PMID: 20413539
    6. It suggested that there could be a combination of GLA deficiency and FVL or other thrombosis-related gene defect in patients with genetic severe early-onset thrombosis. PMID: 20533258
    7. that the murine platelet FV compartment is derived exclusively from primary biosynthesis within cells of marrow origin and an intact platelet FV pool is not required for protection from spontaneous hemorrhage or bleeding following minor trauma PMID: 12816857
    8. the murine platelet and plasma FV pools are biosynthetically distinct PMID: 12855561
    9. The source of the FVL leading to accelerated thrombosis appears to be circulating, non-platelet-derived plasma FVL. PMID: 15809370
    10. FVL has the ability to improve the hemophilia A or B phenotype, but this effect is principally evident at the microcirculation level following a particular vascular injury. PMID: 16359510
    11. observations demonstrate a synergistic interaction between alpha-galactosidase A deficiency and Factor V Leiden toward tissue fibrin deposition; concomitant mutations in these genes may increase the penetrance of vascular thrombotic events in humans PMID: 16514103
    12. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. PMID: 17438064
    13. The FVL mutation has no effect on the development of secondary tumours of colon cancer in livers of mice. PMID: 17635646
    14. FV Leiden allele has no effect in murine colitis and we thus question the importance of activated blood coagulation in the etiology or pathogenesis of inflammatory bowel disease. PMID: 17849058
    15. the factor V Leiden mutation is associated with enhanced thrombotic tendency after FeCl3 injury of the femoral artery on a standard fat diet, but not a high fat diet PMID: 17938812
    16. In contrast to humans, pregnancy induced a decrease in APC resistance in wild-type and in FV Leiden mice. PMID: 19036061
    17. Homozygous Factor V could promote atherosclerosis and fibrin deposition in apolipoprotein E deficient mice. PMID: 19671356

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Multicopper oxidase family
  • 数据库链接：

    KEGG: mmu:14067

    STRING: 10090.ENSMUSP00000083204

    UniGene: Mm.12900