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  4. Recombinant Mouse Coiled-coil domain-containing protein 22 (Ccdc22)

Recombinant Mouse Coiled-coil domain-containing protein 22 (Ccdc22)

  • 中文名称：
    Recombinant Mouse Coiled-coil domain-containing protein 22(Ccdc22),Yeast
  • 货号：
    CSB-YP862366MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Coiled-coil domain-containing protein 22(Ccdc22),Yeast
  • 货号：
    CSB-EP862366MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Coiled-coil domain-containing protein 22(Ccdc22),Yeast
  • 货号：
    CSB-EP862366MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Coiled-coil domain-containing protein 22(Ccdc22),Yeast
  • 货号：
    CSB-BP862366MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Coiled-coil domain-containing protein 22(Ccdc22),Yeast
  • 货号：
    CSB-MP862366MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ccdc22
  • Uniprot No.：
  • 别名：
    Ccdc22; DXImx40eCoiled-coil domain-containing protein 22
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-627
  • 氨基酸序列
    MEEADRILIH SLRQAGTAVP PEVQTLRAFT TELVVEAVVR CLRVINPDVG SGLSHLLPPA MSARFRLAMS LAQACMDLGY PLELGYQNFL YPSEPDLRDL LLFLAERLPS DASEDADQPA GDSAIFLRAI GSQIRDQLAL PWVPPLLRTP KVQRLQGSAL QQPFHSSRLV LPELNSSGEL WEFQASPLLL PAPTQVPQLQ GRAASLLEHH ASQLCQHVNR DCPGDEDRVR WASRVPSQED SRAPQQRLHK QLIEHLRQSW GPLGAPTQVR DLGEMLQTWG ARAMTGVPKG SRFTHSEKFT FHLEPQVQAA QVADVPATSQ RLEQDTRAAQ EQELESLREQ LASVNHNIEE VEADMKTLGI NLVQVETECR QSELSVAEQE QALRLKSRTV ELLPDGAANL AKLQLVVESS AQRLIHLASQ WEKHRVPLLA EYRHLRRLQD CRELESSRRL AEIQELHHSV RAAAEEARRK EEVYKQLVSE LETLPKDVSR LAYTQRILEI VGNIRKQKEE ITKILSDTKE LQKEINSLSG KLDRTFAVTD ELVFKDAKKD DAVRKAYKYL AALHENCSQL IQTIEDTGTI MREVRDLEEQ IETEMGKKTL SNLEKICEDY RALRQENAGL LGRVREA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.
  • 基因功能参考文献：
    1. Identifies this protein as a copine-binding protein. PMID: 12522145
  • 亚细胞定位：
    Endosome.
  • 蛋白家族：
    CCDC22 family
  • 数据库链接：

    KEGG: mmu:54638

    STRING: 10090.ENSMUSP00000033483

    UniGene: Mm.288192