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  4. Recombinant Mouse Cytochrome P450 4A12A (Cyp4a12a)

Recombinant Mouse Cytochrome P450 4A12A (Cyp4a12a)

  • 中文名称：
    Recombinant Mouse Cytochrome P450 4A12A(Cyp4a12a),Yeast
  • 货号：
    CSB-YP842031MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cytochrome P450 4A12A(Cyp4a12a),Yeast
  • 货号：
    CSB-EP842031MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cytochrome P450 4A12A(Cyp4a12a),Yeast
  • 货号：
    CSB-EP842031MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cytochrome P450 4A12A(Cyp4a12a),Yeast
  • 货号：
    CSB-BP842031MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cytochrome P450 4A12A(Cyp4a12a),Yeast
  • 货号：
    CSB-MP842031MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cyp4a12a
  • Uniprot No.：
  • 别名：
    Cyp4a12a; Cyp4a12Cytochrome P450 4A12A; EC 1.14.14.1; CYPIVA12
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-508
  • 氨基酸序列
    MSASALSSIR FPGSISEYLQ VASVLSLLLL LFKTAQLYLH RQWLLSSTQQ FPSPPSHWLF GHKILKDQDL QDILTRIKNF PSACPQWLWG SKVRIQVYDP DYMKLILGRS DPKANGSYRF LAPWIGRGLL MLDGQTWFQH RRMLTPAFHY DILKPYTEIM ADSVRVMLDK WEQIVGQDST LEIFRHITLM TLDTIMKCAF SHEGSVQLDR KYKSYIQAVE DLNDLVFSRV RNIFHQNDII YRVSSNGCKA NSACKLAHDH TDQVIKSRRI QLQDEEELEK LKKKRRLDFL DILLFARMEN GKSLSDKDLR AEVDTFMFEG HDTTASGISW IFYALATNPE HQQRCRKEIQ SLLGDGTSIT WNDLDKMPYT TMCIKEALRI YPPVPSVSRE LSSPVTFPDG RSLPKGIHVM LSFYGLHHNP TVWPNPEVFD PSRFAPGSSR HSHSFLPFSG GARNCIGKQF AMNELKVAVA LTLLRFELLP DPTRVPIPIP RIVLKSKNGI HLHLKKLQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids. May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney. Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Further catalyzes successive omega-oxidations of 20-HETE to the corresponding dicarboxylic acid, and may contribute to the degradation of PUFA by chain shortening. Acts as an omega-hydroxylase and epoxidase toward (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoc acid (EPA). Catalyzes stereoselective epoxidation of the last double bond of EPA, displaying a strong preference for the (R,S) stereoisomer. Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency.
  • 基因功能参考文献：
    1. Enzyme is the predominant 20-hydroxyeicosatetraenoic synthase in mouse kidney. PMID: 17112342
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Gender- and strain-specific expression in kidney (at protein level). Predominantly expressed in males, the expression among strains decreasing in the following order: NMRI > FVB/N > 129 Sv/J > Balb/c > C57BL/6. Expressed in renal arterioles.
  • 数据库链接：

    KEGG: mmu:277753

    STRING: 10090.ENSMUSP00000081370

    UniGene: Mm.276106