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  4. Recombinant Mouse Death domain-containing membrane protein NRADD (Nradd), partial

Recombinant Mouse Death domain-containing membrane protein NRADD (Nradd), partial

  • 中文名称：
    小鼠Nradd重组蛋白
  • 货号：
    CSB-YP814560MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Nradd重组蛋白
  • 货号：
    CSB-EP814560MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Nradd重组蛋白
  • 货号：
    CSB-EP814560MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Nradd重组蛋白
  • 货号：
    CSB-BP814560MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Nradd重组蛋白
  • 货号：
    CSB-MP814560MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nradd
  • Uniprot No.：
  • 别名：
    Nradd; Death domain-containing membrane protein NRADD; Neurotrophin receptor homolog-2; NRH2; Neurotrophin receptor-alike death domain protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR.
  • 基因功能参考文献：
    1. The NRADD conditional and complete knockout mouse lines generated are new and useful tools to study the physiological roles of NRADD. PMID: 27775873
    2. Its reduction ameliorates cognitive deficits in Alzheimer disease. PMID: 25443284
    3. These results suggest a mechanism involving both the transmembrane domain and the death domain of p45 to regulate p75-mediated signaling. PMID: 25093680
    4. p45 forms a complex with FADD and diminishes Fas-FADD mediated death signaling. PMID: 23935974
    5. The s show that the mammalian p75NTR homologue NRH2 critically regulates the expression of sortilin on the neuronal cell surface and promotes p75NTR and sortilin receptor complex formation, rendering cells responsive to proneurotrophins. PMID: 19407813

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  • 亚细胞定位：
    Cell membrane; Single-pass type III membrane protein. Nucleus. Note=Proteolytic processing gives rise to an intracellular domain that translocates to the nucleus.
  • 组织特异性：
    Detected in lung and testis.
  • 数据库链接：

    KEGG: mmu:67169

    STRING: 10090.ENSMUSP00000035069

    UniGene: Mm.46680