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  4. Recombinant Mouse Dyslexia susceptibility 1 candidate gene 1 protein homolog (Dyx1c1)

Recombinant Mouse Dyslexia susceptibility 1 candidate gene 1 protein homolog (Dyx1c1)

  • 中文名称：
    小鼠Dnaaf4重组蛋白
  • 货号：
    CSB-YP844448MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dnaaf4重组蛋白
  • 货号：
    CSB-EP844448MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dnaaf4重组蛋白
  • 货号：
    CSB-EP844448MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dnaaf4重组蛋白
  • 货号：
    CSB-BP844448MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dnaaf4重组蛋白
  • 货号：
    CSB-MP844448MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dnaaf4
  • Uniprot No.：
  • 别名：
    Dnaaf4; Dyx1c1; Ekn1Dynein assembly factor 4; axonemal; Dyslexia susceptibility 1 candidate gene 1 protein homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-420
  • 氨基酸序列
    MPVRVSEFSW QQTPATIFLS LPLRGVCVRD ADVFCGESYL KVNFPPFLFE LFLYAPIDDG KSKAKIGNDT ILFTLYKKEP VLWDSLSVPG VDKEMMQRIR EKSILQAQEK AKEATEAKAV AKREDQRYAL GEMMKIEEEE RKKIEDMKEN ERKKATSELE AWKECQKKAD GQKRVQRKEK PLEGKQAEET KALKPRGLPR KAPPTRLPTR GRNWENIFPE KLKEDRVPAP RSAGSIQISF TPRVFPTALR ESQVAEEEEW LHKQAEARRA MSTDLPEFFD LKEEERNPDW LKDKGNKLFA TENYLAAVDA YNLAIRLNCK IPLLYLNRAA CHLKLKNLHK AIEDSSKALE LLTPPVADNA NARMKAHVRR GTAFCQLELY VEGLQDYEAA LKIDPANTVV QNDAEKIRNI IQGTALKSRD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. Axonemal dynein assembly factor required for ciliary motility.
  • 基因功能参考文献：
    1. In total, four independent SNPs within DYX1C1 and ATP2C2 were found to be associated with MMR stronger than expected from multiple testing. To explore potential pathomechanisms, we annotated these variants with functional data including tissue-specific expression analysis and eQTLs. PMID: 29201552
    2. findings in mice affirm existing evidence that DYX1C1 may play an underlying role in the development of neural systems important to learning and memory, and disruption of this function could contribute to the learning deficits seen in individuals with dyslexia PMID: 25989970
    3. DYX1C1 is required for axonemal dynein assembly and ciliary motility. PMID: 23872636
  • 亚细胞定位：
    Nucleus. Cytoplasm. Dynein axonemal particle. Cell projection, neuron projection.
  • 数据库链接：

    KEGG: mmu:67685

    STRING: 10090.ENSMUSP00000034734

    UniGene: Mm.31817