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  4. Recombinant Mouse E3 ubiquitin-protein ligase LRSAM1 (Lrsam1)

Recombinant Mouse E3 ubiquitin-protein ligase LRSAM1 (Lrsam1)

  • 中文名称：
    小鼠Lrsam1重组蛋白
  • 货号：
    CSB-YP768923MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Lrsam1重组蛋白
  • 货号：
    CSB-EP768923MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Lrsam1重组蛋白
  • 货号：
    CSB-EP768923MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Lrsam1重组蛋白
  • 货号：
    CSB-BP768923MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Lrsam1重组蛋白
  • 货号：
    CSB-MP768923MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lrsam1
  • Uniprot No.：
  • 别名：
    Lrsam1; E3 ubiquitin-protein ligase LRSAM1; EC 2.3.2.27; Leucine-rich repeat and sterile alpha motif-containing protein 1; RING-type E3 ubiquitin transferase LRSAM1; Tsg101-associated ligase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-727
  • 氨基酸序列
    MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LSEIPFGAFA TCKVLQKKVL IVHTNHLTSL LPKSCSLLSL VTIKVLDLHE NQLTALPDDM GQLTVLQVLN VERNQLTHLP RSIGNLLQLQ TLNVKDNKLK ELPDTLGELR SLRTLDISEN EIQRLPQMLA HVRTLETLSL NALAMVYPPP EVCGAGTAAV QQFLCKESGL DYYPPSQYLL PVLEQDGAEN TQDSPDGPAS RFSREEAEWQ NRFSDYEKRK EQKMLEKLEF ERRLDLGQRE HAELLQQSHS HKDEILQTVK QEQTRLEQDL SERQRCLDAE RQQLQEQLKQ TEQSIASRIQ RLLQDNQRQK KSSEILKSLE NERIRMEQLM SITQEETENL RQREIAAAMQ QMLTESCKSR LIQMAYESQR QSLAQQACSS MAEMDKRFQQ ILSWQQMDQN KAISQILQES VMQKAAFEAL QVKKDLMHRQ IRNQIRLIET ELLQLTQLEL KRKSLDTETL QEMVSEQRWA LSNLLQQLLK EKKQREEELH GILAELEAKS ETKQENYWLI QYQRLLNQKP LSLKLQEEGM ERRLVALLVE LSAEHYLPLF AHHRISLDML SRMSPGDLAK VGVSEAGLQH EILRRAQDLL AVPRVQPELK PLENEVLGAL EPPTAPRELQ ESVRPSAPPA ELDMPTSECV VCLEREAQMV FLTCGHVCCC QQCCQPLRTC PLCRQEISQR LRIYHSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (viral proteins) cargos. Bacterial recognition protein that defends the cytoplasm from invasive pathogens. Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy).
  • 基因功能参考文献：
    1. TLR4/NF-kappaB-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury. PMID: 25692136
    2. Lrsam1 mutant mice are more sensitive to challenge with acrylamide, a neurotoxic agent that causes axon degeneration, indicating that the axons in the mutant mice are indeed compromised. PMID: 23519028
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    KEGG: mmu:227738

    STRING: 10090.ENSMUSP00000028132

    UniGene: Mm.248037