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  4. Recombinant Mouse E3 ubiquitin-protein ligase Praja-1 (Pja1)

Recombinant Mouse E3 ubiquitin-protein ligase Praja-1 (Pja1)

  • 中文名称：
    小鼠Pja1重组蛋白
  • 货号：
    CSB-YP018049MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pja1重组蛋白
  • 货号：
    CSB-EP018049MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pja1重组蛋白
  • 货号：
    CSB-EP018049MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pja1重组蛋白
  • 货号：
    CSB-BP018049MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pja1重组蛋白
  • 货号：
    CSB-MP018049MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pja1
  • Uniprot No.：
  • 别名：
    Pja1; E3 ubiquitin-protein ligase Praja-1; Praja1; EC 2.3.2.27; RING-type E3 ubiquitin transferase Praja-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-578
  • 氨基酸序列
    MSHQERIASQ RRTTAEVPMH RSTANQSKRS RSPFASTRRR WDDSESSGAS LAVESEDYSR YPPREYRASG SRRGLAYGHI DTVVARDSEE EGAGPVDRLP VRGKAGKFKD DPEKGARSSR FTSVNHDAKE ECGKVESPPA ARCSARRAEL SKQNGSSASQ ISSAEGRAAA KGNNSLERER QNLPARPSRA PVSICGGGEN TPKSAEEPVV RPKVRNVATP NCMKPKVFFD TDDDDDVPHS TSRWRDAADA EEAHAEGLAR RGRGEAASSS EPRYAEDQDA RSEQAKADKV PRRRRTMADP DFWAYTDDYY RYYEEDSDSD KEWMAALRRK YRSREQPQSS SGESWELLPG KEELERQQAG AGSLASAGSN GSGYPEEVQD PSLQEEEQAS LEEGEIPWLR YNENESSSEG DNESTHELIQ PGMFMLDGNN NLEDDSSVSE DLEVDWSLFD GFADGLGVAE AISYVDPQFL TYMALEERLA QAMETALAHL ESLAVDVEVA NPPASKESID ALPEILVTED HGAVGQEMCC PICCSEYVKG EVATELPCHH YFHKPCVSIW LQKSGTCPVC RCMFPPPL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting.
  • 基因功能参考文献：
    1. Praja1 promotes skeletal myogenesis through degradation of EZH2 upon p38alpha activation. PMID: 28067271
  • 组织特异性：
    Expressed in brain, liver, kidney. Highest levels in brain where it is found in many regions including cortical and subcortical areas and in neurons of the amygdala. Weak expression also found in testis. Also expressed in developing embryo.
  • 数据库链接：

    KEGG: mmu:18744

    STRING: 10090.ENSMUSP00000109420

    UniGene: Mm.8211