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  4. Recombinant Mouse E3 ubiquitin-protein ligase TRIM11 (Trim11)

Recombinant Mouse E3 ubiquitin-protein ligase TRIM11 (Trim11)

  • 中文名称：
    小鼠Trim11重组蛋白
  • 货号：
    CSB-YP859586MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Trim11重组蛋白
  • 货号：
    CSB-EP859586MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Trim11重组蛋白
  • 货号：
    CSB-EP859586MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Trim11重组蛋白
  • 货号：
    CSB-BP859586MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Trim11重组蛋白
  • 货号：
    CSB-MP859586MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trim11
  • Uniprot No.：
  • 别名：
    Trim11; E3 ubiquitin-protein ligase TRIM11; EC 2.3.2.27; RING-type E3 ubiquitin transferase TRIM11; Tripartite motif-containing protein 11
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-467
  • 氨基酸序列
    MAAPDLSTNL QEEATCAICL DYFTDPVMTD CGHNFCRECI RRCWGQPEGP YACPECRELS AQRNLRPNRP LAKMAEMARR LHPPSPVPQG VCAAHREPLT TFCGDDLSLL CPICERSEHW THRVRPLQEA ADDLKGRLEK SLEHLRKQME DAMLFQAQAE ETCALWQKMV ESQRQNVLGE FERLRRLLAE EEQQLLQKLE EEELEVLPRL REGAARLGQQ STQLAALISE LESRCQLPAL GLLQDIKDAL CRVQDVKLQP PAVVPMELRT VCRVPGLVET LRRFRGDITL DPDTANPELV LSEDRRSVQR GEQRQALPDN PERFDPGPCV LGQERITSGR HYWEVEVGDQ TSWALGVCKE TANRKEKGEL SAGNGFWILV FLGSFYNSNE PAFSPLRDPP KRVGIFLDYE AGHLSFYSAT DGSLLFIFPE TLFSGTLRPL FSPLSSSPTP MTICRLIGVS GDTLGPQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
  • 基因功能参考文献：
    1. TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy. PMID: 27498865
    2. The results suggest that TRIM11 plays a role in the regulation of intracellular humanin level through ubiquitin-mediated protein degradation pathways. PMID: 12670303
  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=In the nucleus, colocalizes with PAX6.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Expressed in embryonic central nervous system (CNS), kidney, thymus and gut.
  • 数据库链接：

    KEGG: mmu:94091

    STRING: 10090.ENSMUSP00000090749

    UniGene: Mm.248049