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  4. Recombinant Mouse Forkhead box protein E1 (Foxe1)

Recombinant Mouse Forkhead box protein E1 (Foxe1)

  • 中文名称：
    小鼠Foxe1重组蛋白
  • 货号：
    CSB-YP844440MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Foxe1重组蛋白
  • 货号：
    CSB-EP844440MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Foxe1重组蛋白
  • 货号：
    CSB-EP844440MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Foxe1重组蛋白
  • 货号：
    CSB-BP844440MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Foxe1重组蛋白
  • 货号：
    CSB-MP844440MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Foxe1
  • Uniprot No.：
  • 别名：
    Foxe1; Titf2Forkhead box protein E1; Thyroid transcription factor 2; TTF-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-371
  • 氨基酸序列
    MTAESAPPPP PQPETLAAVK EERGEAAAAG AGVPAEAAGR GAGGRRRKRP LQRGKPPYSY IALIAMAIAH APERRLTLGG IYKFITERFP FYRDNPKKWQ NSIRHNLTLN DCFLKIPREA GRPGKGNYWA LDPNAEDMFE SGSFLRRRKR FKRSDLSTYP AYMHDAAAAA AAAAAAIFPG AVPAARPAYP GAVYAGYAPP LAAPPPVYYP AASPGPCRVF GLVPERPLSP DLGPAPSAAG GSCAFAAAAG AAGTGSFQPA VCTGARPVNP AAYAAAYAGP DGAYPQGASS ALFAAAAGRL AGPASPPAGG GSGGVEATVD FYGRTSPGQF GAALGPCYNP GGQLGAGGGG AYHSRHATAY PGAVDRFVSA M
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.
  • 基因功能参考文献：
    1. These results indicate that Foxe1 overexpression is not directly involved in the development of thyroid cancer and that proper Foxe1 dosage is essential for achieving normal structure and function of the thyroid. PMID: 26982637
    2. Foxe1 mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes. PMID: 21777520
    3. MSX1 and TGF-beta3 are direct targets of FOXE1. PMID: 21177256
    4. Data report a detailed expression pattern of thyroid transcription factor-2 protein during mouse embryogenesis. PMID: 12203737
    5. Foxe1 is required for hair follicle morphogenesis. PMID: 15367491

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in Rathke pouch, in thyroid, and in the epithelium of the pharyngeal wall and arches, whereas it is absent in the epithelium of the pharyngeal pouches.
  • 数据库链接：

    KEGG: mmu:110805

    STRING: 10090.ENSMUSP00000092715

    UniGene: Mm.354634