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  4. Recombinant Mouse Forkhead box protein P4 (Foxp4)

Recombinant Mouse Forkhead box protein P4 (Foxp4)

  • 中文名称：
    小鼠Foxp4重组蛋白
  • 货号：
    CSB-YP880565MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Foxp4重组蛋白
  • 货号：
    CSB-EP880565MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Foxp4重组蛋白
  • 货号：
    CSB-EP880565MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Foxp4重组蛋白
  • 货号：
    CSB-BP880565MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Foxp4重组蛋白
  • 货号：
    CSB-MP880565MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Foxp4
  • Uniprot No.：
  • 别名：
    Foxp4Forkhead box protein P4; Fork head-related protein-like A; mFKHLA
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-795
  • 氨基酸序列
    MMVESASETI RSAPSGQNGV GSLSAQADGG GGAGTAGTAP AAGRDASGRE AASGGADSNG EMSPAELLHF QQQQALQVAR QFLLQQASSL NSPGNNDSKQ SASAVQVPVS VAMMSQQMLT PQQMQQILSP PQLQALLQQQ QALMLQQLQE YYKKQQEQLH LQLLTQQQAG KQQPKEALGN KQLAFQQQLL QMQQLQQQHL LNLQRQGLVS LQPSQASGPL QALPQAVCPT DLPQLWKGEG APGQPAEDSG RQEGLDLAST AVTATSFASP PKVSPPLSHH PLPNGQPTVL TSRRDSSSHE ETPSSHPLYG HGECKWPGCE TLCEDLGQFI KHLNTEHALD DRSTAQCRVQ MQVVQQLEIQ LAKESERLQA MMAHLHMRPS EPKPFSQPVT VSADPFPDGL VHPPTSAAAP VTPLRPPGLG SASLHSGGPA RRRSNDKFCS PISSELAQNH EFYKNADVRP PFTYASLIRQ AILETPDRQL TLNEIYNWFT RMFAYFRRNT ATWKNAVRHN LSLHKCFVRV ENVKGAVWTV DEREYQKRRP PKMTGSPTLV KNMISGLSYG ALNASYQAAL AESSFPLLSN PGMLNPGSAS SLLPLSQEDL GVPGEPLPSN GSSSPPRLSP PQYSHQIQVK EEPAEAEEDR RPGPPLGAPN PSTVGPPEDR DLEEDLGGED MPSQPCPLIP GWKPSLLHLS YCVKPKFTVS VGSKTPSSPL PPPPRVQGSY SLPPCSYLAY GDMRGQNPAP SPGLLSGVGG GLFRCLHRTK SPSLPGVWIL AAELETMRFH RPPMGDPQPK TADWV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor that represses lung-specific expression.
  • 基因功能参考文献：
    1. Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Ectopic expression of these transcriptional regulators is accompanied by decreased expression of lung restricted transcription. PMID: 27341756
    2. Collectively, these findings reveal an important role for the FOXP1, 2, and 4 proteins in governing postnatal alpha cell expansion and function. PMID: 26021489
    3. Foxp1/2/4 may regulate Runx2 during endochondral ossification. PMID: 25527076
    4. Loss of Foxp1/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase anterior gradient 2 (Agr2). PMID: 22675208
    5. the data of this study revealed a Foxp-based transcriptional mechanism that regulates the integrity and cytoarchitecture of neuroepithelial progenitors PMID: 22542185
    6. Foxp4 is dispensable for the early Purkinje cell (PC) dendrite outgrowth but is essential for the maintenance of PC dendritic arborization and subsequent association with Bergmann glial fibers. PMID: 20951773
    7. Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6. PMID: 20185820
    8. Foxp4 is expressed exclusively in the epithelial cells of the developing intestine, where, in late development, it is expressed in a gradient along the longitudinal axis of the villi PMID: 12617805
    9. In adult tissues FoxP4 is expressed in heart, brain, lung, liver, kidney, and testis.In situ hybridization revealed expression of FoxP4 in the developing lung and gut PMID: 12818433
    10. complex regulatory mechanism underlying Foxp1, Foxp2, and Foxp4 activity, demonstrating that Foxp1, Foxp2, and Foxp4 are the first Fox proteins reported whose activity is regulated by homo- and heterodimerization PMID: 14701752

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in the adult heart, brain, spleen lung, liver, kidney and testes.
  • 数据库链接：

    KEGG: mmu:74123

    STRING: 10090.ENSMUSP00000094916

    UniGene: Mm.240062