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  4. Recombinant Mouse G-protein-signaling modulator 1 (Gpsm1)

Recombinant Mouse G-protein-signaling modulator 1 (Gpsm1)

  • 中文名称：
    小鼠Gpsm1重组蛋白
  • 货号：
    CSB-YP746934MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gpsm1重组蛋白
  • 货号：
    CSB-EP746934MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gpsm1重组蛋白
  • 货号：
    CSB-EP746934MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gpsm1重组蛋白
  • 货号：
    CSB-BP746934MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gpsm1重组蛋白
  • 货号：
    CSB-MP746934MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gpsm1
  • Uniprot No.：
  • 别名：
    Gpsm1; Ags3; C10aG-protein-signaling modulator 1; Activator of G-protein signaling 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-673
  • 氨基酸序列
    MASPAPPVAE ELPGPASRRL YSRMEASCLE LALEGERLCK AGDFKAGVAF FEAAVQVGTE DLKTLSAIYS QLGNAYFYLK EYARALQFHK HDLLLARTIG DRMGEAKASG NLGNTLKVLG RFDEAIVCCQ RHLDIAQEQG DKVGEARALY NIGNVYHAKG KQLSWNAAQD PGHLPPDVRE TLHRASEFYE RNLSLVKELG DRAAQGRAYG NLGNTHYLLG NFTEATTFHK ERLAIAKEFG DKAAERRAYS NLGNAHIFLG RFDVAAEHYK KTLQLSRQLR DQAVEAQACY SLGNTYTLLQ DYERAAEYHL RHLVIAQELA DRVGEGRACW SLGNAYVSMG SPAQALTFAK KHLQISQEIG DRNGELTARM NIAHLQLALG RLTSPAAAEK PDLAGYEAQG ARPKRTQRLS AETWDLLRLP LDREQNGETH HTGDWRGPGR DSLPLPMRSR KYQEGPDAIE RRPREGSHSP LDSADVRVQV PRTGIPRAPS SDEECFFDLL SKFQSSRMDD QRCPLEEGQA GAAEATAAPS VEDRAAQSSV TASPQTEEFF DLIASSQSRR LDDQRASVGS LPGLRITLNN VGHLRGDGDA QEPGDEFFNM LIKYQSSRID DQRCPPPDVL PRGPTMPDED FFSLIQRVQA KRMDEQRVDL AGSPEQEASG LPDPQQQCPP GAS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
  • 基因功能参考文献：
    1. findings show that AGS3 is not required for planar divisions of neural progenitors in the mouse neocortex. AGS3 is not recruited to the cell cortex and does not rescue LGN loss of function. PMID: 28684399
    2. We conclude that LPS priming increases AGS3 levels, which enhances lysosomal function and increases the capacity of macrophages to eliminate intracellular pathogens. PMID: 26667172
    3. level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3, AGS3, or RGS19; or had been treated with pertussis toxin, were similar to controls PMID: 24312373
    4. AGS3 has a role in the regulation of G-protein signaling in the immune system PMID: 24573680
    5. these results indicate that GRK6 complexes with AGS3-Galphai2 to regulate CXCR2-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane. PMID: 24510965
    6. The present study demonstrates an important role for GPSM1 in controlling the dynamics of cyst progression in an orthologous mouse model of autosomal dominant polycystic kidney disease. PMID: 23236168
    7. These data suggest that Gpsm1 acts through a novel receptor-independent mechanism to facilitate renal tubular epithelial cell proliferation and renal tubular regeneration. PMID: 21343176
    8. cortical localization in mitotic cell culture systems and requirement for normal cell cycle progression PMID: 12925752
    9. AGS3 null mice exhibited a lean phenotype, reduced fat mass, and increased nocturnal energy expenditure. PMID: 18450958
    10. The GPR motif in this protein and other proteins is actually associated with activity as a GDI - guanine nucleotide dissociation inhibitor and not GTPase activator as initially suggested. PMID: 10969064

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  • 亚细胞定位：
    Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    GPSM family
  • 组织特异性：
    Expressed in neural progenitor cells (at protein level).
  • 数据库链接：

    KEGG: mmu:67839

    STRING: 10090.ENSMUSP00000067964

    UniGene: Mm.266611