Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse GDNF family receptor alpha-2 (Gfra2)

Recombinant Mouse GDNF family receptor alpha-2 (Gfra2)

  • 中文名称：
    小鼠Gfra2重组蛋白
  • 货号：
    CSB-YP009380MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gfra2重组蛋白
  • 货号：
    CSB-EP009380MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gfra2重组蛋白
  • 货号：
    CSB-EP009380MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gfra2重组蛋白
  • 货号：
    CSB-BP009380MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gfra2重组蛋白
  • 货号：
    CSB-MP009380MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gfra2
  • Uniprot No.：
  • 别名：
    Gfra2; Gdnfrb; Trnr2GDNF family receptor alpha-2; GDNF receptor alpha-2; GDNFR-alpha-2; GFR-alpha-2; GDNF receptor beta; GDNFR-beta; Neurturin receptor alpha; NRTNR-alpha; NTNR-alpha; TGF-beta-related neurotrophic factor receptor 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-443
  • 氨基酸序列
    SPSSPQGSE LHGWRPQVDC VRANELCAAE SNCSSRYRTL RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS CSYEDKEKPN CLDLRSLCRT DHLCRSRLAD FHANCRASYR TITSCPADNY QACLGSYAGM IGFDMTPNYV DSNPTGIVVS PWCNCRGSGN MEEECEKFLK DFTENPCLRN AIQAFGNGTD VNMSPKGPTF SATQAPRVEK TPSLPDDLSD STSLGTSVIT TCTSIQEQGL KANNSKELSM CFTELTTNIS PGSKKVIKLY SGS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.; participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.
  • 基因功能参考文献：
    1. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase. PMID: 27396331
    2. Ret and Gfra2 null mice display comparable early central projection deficits, but Gfra2 null rapidly adapting mechanoreceptors recover later. PMID: 25838128
    3. neurons switch their GFRalpha signaling pathways during postnatal development PMID: 25111710
    4. STAT3 phosphorylation by neurturin was found to be mediated specifically by GFRalpha2c and RET9 isoforms. PMID: 23872421
    5. Cholinergic innervation of gastric mucosa depends on neurturin-GFRalpha2 signalling but is dispensable for gastrin secretion and for basal and maximal acid output PMID: 23339174
    6. Transduction-function role for GFR alpha2/neurturin signalling in a specific class of sensory neurons. PMID: 12433948
    7. growth retardation in mice lacking GFRalpha2 is largely due to impaired salivary and pancreatic secretion and intestinal dysmotility. PMID: 12952919
    8. The cholinergic subpopulation of sympathetic neurons requires GFR alpha 2 signaling for soma size and for growth or maintenance of target innervation. PMID: 15234349
    9. The knockout mice of GFRalpha2 displayed significant impairment in contextual fear conditioning and conditioned taste aversion tests of memory. PMID: 15245503
    10. GFRalpha2 signaling is needed for development of the parasympathetic islet innervation that is critical for vagally induced hormone secretion. PMID: 15855316
    11. Critical role for endogenous GFRalpha2 signaling in maintaining the size and terminal innervation of the nonpeptidergic class of cutaneous nociceptors in vivo. PMID: 16481427
    12. Increased apoptosis of parasympathetic but not enteric neurons in the developing pancreas of mice lacking GFRalpha2. PMID: 17355878

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    GDNFR family
  • 组织特异性：
    Neurons of the superior cervical and dorsal root ganglia, and adult brain and testis. Low level in the substantia nigra, spleen and adrenal gland. Isoform 1, isoform 2 and isoform 3 are all expressed in brain, liver, ileum, spleen, heart and kidney. In br
  • 数据库链接：

    KEGG: mmu:14586

    STRING: 10090.ENSMUSP00000022699

    UniGene: Mm.32619