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  4. Recombinant Mouse GTP-binding protein REM 1 (Rem1)

Recombinant Mouse GTP-binding protein REM 1 (Rem1)

  • 中文名称：
    小鼠Rem1重组蛋白
  • 货号：
    CSB-YP019559MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rem1重组蛋白
  • 货号：
    CSB-EP019559MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rem1重组蛋白
  • 货号：
    CSB-EP019559MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rem1重组蛋白
  • 货号：
    CSB-BP019559MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rem1重组蛋白
  • 货号：
    CSB-MP019559MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rem1
  • Uniprot No.：
  • 别名：
    Rem1; Rem; GTP-binding protein REM 1; Rad and Gem-like GTP-binding protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-297
  • 氨基酸序列
    MTLNTQQEAK TTLRRRASTP LPLSSRGHQP GRLCTAPSAP SQHPRLGQSV SLNPPVRKPS PAQDGWSSES SDSEGSWEAL YRVVLLGDPG VGKTSLASLF AEKQDRDPHE QLGGVYERTL SVDGEDTTLV VMDTWEAEKL DESWCQESCL QAGSAYVIVY SIADRSSFES ASELRIQLRR THQANHVPII LVGNKADLAR CREVSVEEGR ACAVVFDCKF IETSATLQHN VTELFEGVVR QLRLRRQDNA APETPSPRRR ASLGQRARRF LARLTARSAR RRALKARSKS CHNLAVL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling.
  • 基因功能参考文献：
    1. These results reveal that similar molecular determinants on Rem are repurposed to initiate 2 independent mechanisms of CaV1.2 inhibition. PMID: 27115600
    2. Rad, Gem and Rem all reduce depolarization-dependent Ca2+ entry in developing myotubes. PMID: 24476902
    3. amino-termini of Rad and Rem as the structural elements dictating the specific modes of inhibition of CaV1.1 PMID: 24806927
    4. Loss of an REM1 protein increased L-type calcium current density in vivo in cardiac myocytes. PMID: 22854599
    5. both Rem and Rad bind directly to Ca2+ channel beta-subunits (CaV beta) in vivo PMID: 14623965
    6. We conclude that Rem is capable of regulating L-type current, that release of Rem block is modulated by cellular kinase pathways, and that the Ca(V)1.2 COOH terminus contributes to Rem-dependent channel inhibition. PMID: 16648185
    7. Rem-dependent Ca2+ channel modulation involves formation of a Rem x CaVbeta x alpha-interaction domain regulatory complex without the need to disrupt CaValpha1 x CaVbeta association or alter CaValpha1 expression at the plasma membrane. PMID: 16790445
    8. Nuclear localization of RGK proteins (Rad, Rem, and Rem2) contributes to the suppression of RGK-mediated cell shape remodeling. PMID: 17605760
    9. a role for the Rem C terminus in plasma membrane localization through association with phosphatidylinositol lipids. PMID: 17686775

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  • 蛋白家族：
    Small GTPase superfamily, RGK family
  • 组织特异性：
    High expression in cardiac muscle. Moderate expression in lung, skeletal muscle and kidney. Low levels in spleen and brain.
  • 数据库链接：

    KEGG: mmu:19700

    STRING: 10090.ENSMUSP00000000369

    UniGene: Mm.8752