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  4. Recombinant Mouse GTPase IMAP family member 5 (Gimap5), partial

Recombinant Mouse GTPase IMAP family member 5 (Gimap5), partial

  • 中文名称：
    小鼠Gimap5重组蛋白
  • 货号：
    CSB-YP806445MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gimap5重组蛋白
  • 货号：
    CSB-EP806445MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gimap5重组蛋白
  • 货号：
    CSB-EP806445MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gimap5重组蛋白
  • 货号：
    CSB-BP806445MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gimap5重组蛋白
  • 货号：
    CSB-MP806445MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gimap5
  • Uniprot No.：
  • 别名：
    Gimap5; Ian4l1; Ian5; Imap3; GTPase IMAP family member 5; GTPase of the immunity-associated protein 5; Immunity-associated nucleotide 4-like 1 protein; Immunity-associated protein 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes. Inhibitor of GSK3A. May act by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of bone marrow hematopoietic stem cells, as well as of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function. May promote the survival of mature T lymphocytes upon cytokine withdrawal. May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation. May play a role in mitochondrial DNA segregation in hematopoietic tissues.
  • 基因功能参考文献：
    1. Gimap5 is a critical inhibitor of GSK3-beta in the CD4+ T cells. PMID: 29382851
    2. functional Gimap5 is required for optimal signaling through TCR and IL-7R in T cells. PMID: 27023180
    3. gimap5 has a role in maintaining peripheral tolerance and T cell homeostasis in the gut [review] PMID: 25944983
    4. a novel link between Gimap5 and Foxo expression and provide evidence for a regulatory mechanism that controls Foxo protein expression and may help to maintain immunological tolerance. PMID: 22106000
    5. Gimap5 is an important stabilizer of mouse hematopoietic progenitor cell survival. PMID: 21502331
    6. mouse gimap5 is necessary for the survival of peripheral T cells, NK/NKT-cell development, and the maintenance of normal liver function PMID: 18796632

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  • 亚细胞定位：
    Lysosome membrane; Single-pass type IV membrane protein. Endosome, multivesicular body membrane; Single-pass type IV membrane protein. Endosome membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily
  • 组织特异性：
    Expressed in thymus (in thymocytes), spleen (in splenocytes), lymph node and lung. Highly expressed in T lymphocytes. Expressed in B cells and in distinct lineages of hematopoietic bone marrow cells, including natural killer, B, T, myeloid and erythroid l
  • 数据库链接：

    KEGG: mmu:317757

    STRING: 10090.ENSMUSP00000056820

    UniGene: Mm.455917