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  4. Recombinant Mouse Galactoside 2-alpha-L-fucosyltransferase 2 (Fut2), partial

Recombinant Mouse Galactoside 2-alpha-L-fucosyltransferase 2 (Fut2), partial

  • 中文名称：
    小鼠Fut2重组蛋白
  • 货号：
    CSB-YP862405MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fut2重组蛋白
  • 货号：
    CSB-EP862405MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fut2重组蛋白
  • 货号：
    CSB-EP862405MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fut2重组蛋白
  • 货号：
    CSB-BP862405MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fut2重组蛋白
  • 货号：
    CSB-MP862405MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fut2
  • Uniprot No.：
  • 别名：
    Fut2; Sec2; Galactoside 2-alpha-L-fucosyltransferase 2; EC 2.4.1.344; EC 2.4.1.69; Alpha(1,2)FT 2; Fucosyltransferase 2; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; Secretory blood group protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation. Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway.
  • 基因功能参考文献：
    1. Results indicate that the fucosyltransferase 2 (FUT2) determines the O-glycosylation pattern of mucin-5AC (Muc5ac). PMID: 27161092
    2. Fut2 gene expression is responsible for disease progression in mice with primary sclerosing cholangitis. PMID: 28056490
    3. These data suggest a novel role for Fut2 as a regulator of angiogenesis. PMID: 23065099
    4. Fucosyltransferase Fut)-deficient (Fut1, Fut2 and Fut4) mice which lack LeX or LeY antigen are still fertile. PMID: 20876654
    5. These data demonstrate that epithelial Fut2 mRNA expression is regulated by factors including LIF and IL1B secreted from macrophages recruited during the inflammatory response to insemination. PMID: 20864644
    6. open reading frame encoded 347 amino acids with a predicted molecular mass of 39.21 kDa and exhibited sequence homology with murine H & Sec1 gene[alpha1,2-fucosyltransferase ] PMID: 16416971
    7. An impairment of BabA-dependent adhesion of H. pylori to Fut2-null mice gastric mucosa, whereas SabA-mediated binding was not affected. PMID: 19706747
    8. FUT2-encoded enzyme preferentially participates in the fucosylation of GA1 and GM1 in gastrointestinal tissues. Female reproductive organs were similarly found to utilize FUT2 for the fucosylation of glycolipids FGA1 (uterus and cervix), & FGM1 (ovary). PMID: 14967068

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  • 亚细胞定位：
    Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 11 family
  • 组织特异性：
    Expressed in stomach, colon, ovary and uterus, specifically in luminal uterine epithelium. Expressed in various tissues including heart, liver, kidney, testis, epididymis, small intestine,and cecum. Expressed in duodenum, jejunum and ileum.
  • 数据库链接：

    KEGG: mmu:14344

    STRING: 10090.ENSMUSP00000063719

    UniGene: Mm.290046