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  4. Recombinant Mouse Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (B3gat1), partial

Recombinant Mouse Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (B3gat1), partial

  • 中文名称：
    Recombinant Mouse Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1(B3gat1),partial,Yeast
  • 货号：
    CSB-YP863446MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1(B3gat1),partial,Yeast
  • 货号：
    CSB-EP863446MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1(B3gat1),partial,Yeast
  • 货号：
    CSB-EP863446MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1(B3gat1),partial,Yeast
  • 货号：
    CSB-BP863446MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1(B3gat1),partial,Yeast
  • 货号：
    CSB-MP863446MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    B3gat1
  • Uniprot No.：
  • 别名：
    B3gat1Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; EC 2.4.1.135; Beta-1,3-glucuronyltransferase 1; Glucuronosyltransferase P; GlcAT-P; UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase; GlcUAT-P
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group.
  • 基因功能参考文献：
    1. We then examined several HNK-1-related antibodies, including the Cat-315 antibody, for reactions with HNK-1-capped core M2 glycans. Finally, we confirmed the increased HNK-1 epitope expression in demyelinated brains of cuprizone-fed mice. PMID: 28427937
    2. Results could lead to discovery of new roles of the human natural killer-1 (HNK-1) epitope in neural plasticity. PMID: 26659409
    3. Alpha-Klotho expression is associated with expression of the non-sulfated HNK-1 epitope. PMID: 24723043
    4. A linear HNK-1 mimetic peptide demonstrates potential as an efficient, feasible, and safe adjunct treatment for nerve injuries requiring surgical repair in cynomolgus monkeys. PMID: 21463132
    5. the specific enzyme complex of beta4GalT-II with GlcAT-P plays an important role in the biosynthesis of HNK-1 carbohydrate. PMID: 21771787
    6. HNK-1 epitope-carrying tenascin-C spliced variant regulates the proliferation of mouse embryonic neural stem cells. PMID: 20855890
    7. A 207 bp fragment of the 5'-upstream region of mouse GlcAT-P gene acts as a strong promoter in PC-12 cells, which express the HNK-1 epitope. PMID: 11872162
    8. HNK-1 deficient mice exhibit impaired synaptic plasticity and spatial learning. (HNK-1, CD57) PMID: 12032138
    9. In development, HNK-1-positive-cells and NCAM-positive cells were seen after P-21. These results suggest that the Schwann cells from the motor and the sensory fascicles have different subtypes. PMID: 16171882
    10. the localization of HNK-1 carbohydrate was restricted partially in the brain of GlcAT-P-deficient mice PMID: 17935701
    11. TonEBP activation by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc PMID: 19147493
    12. HNK-1 epitope on GluR2 regulates cell surface stability of GluR2 by modulating the interaction with N-cadherin PMID: 19729452

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  • 亚细胞定位：
    [Isoform 1]: Golgi apparatus membrane; Single-pass type II membrane protein. Secreted.; [Isoform 2]: Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Secreted.
  • 蛋白家族：
    Glycosyltransferase 43 family
  • 数据库链接：

    KEGG: mmu:76898

    STRING: 10090.ENSMUSP00000125700

    UniGene: Mm.218788