Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Gamma-aminobutyric acid receptor subunit alpha-5 (Gabra5), partial

Recombinant Mouse Gamma-aminobutyric acid receptor subunit alpha-5 (Gabra5), partial

  • 中文名称：
    小鼠Gabra5重组蛋白
  • 货号：
    CSB-YP805896MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gabra5重组蛋白
  • 货号：
    CSB-EP805896MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gabra5重组蛋白
  • 货号：
    CSB-EP805896MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gabra5重组蛋白
  • 货号：
    CSB-BP805896MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gabra5重组蛋白
  • 货号：
    CSB-MP805896MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gabra5
  • Uniprot No.：
  • 别名：
    Gabra5; Gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor subunit alpha-5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ligand-gated chloride channel subunit which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. May be involved in GABA-A receptor assembly, and GABA-A receptor immobilization and accumulation by gephyrin at the synapse.
  • 基因功能参考文献：
    1. findings support the hypothesis that reduced alpha5GABAAR activity contributes to an Autism Spectrum Disorder phenotype. The results also suggest that Gabra5-/- mice may serve as an animal model for ASD, as assessed through EEG activity and sleep-wake behaviors. PMID: 27793660
    2. Deletion of Gabra5 in newborn granule cells caused severe alterations of migration and dendrite development. PMID: 27364953
    3. In the present study explored the contribution of alpha5 subunit-containing GABAARs to tonic inhibition in the dorsal horn and pain processing. PMID: 27792253
    4. Results suggest that alpha1, alpha5 and gamma2-containing hippocampal GABA type A receptors complexes play an essential role in spatial learning and memory in which targeted disruption of the alpha1 subunit produces profound deficits. PMID: 27155990
    5. In conclusion, our findings reveal a role of alpha5-GABAARs in mediating the affective component of benzodiazepine-induced anxiolysis. PMID: 27067130
    6. Report benzodiazepine derivative as GABA-site inhibitor of extra-synaptic GABAA alpha5 receptors. PMID: 26169564
    7. This study describes a novel mechanism that regulates plasma receptor pools in the control of synaptic receptor density. PMID: 25891999
    8. This study demonstrated that alpha5-GABAAR-mediated tonic inhibition in the DG plays an important role in ensuring normal cognitive functioning under high-interference memory conditions. PMID: 26446222
    9. Thus, alpha5GABA(A)R function does not return to baseline after the anesthetic is eliminated, suggesting a mechanism to account for persistent memory deficits after general anesthesia. PMID: 25365226
    10. The results of this study suggested that gabra5 mediated tonic current, which is potentiated by H2O2, might contribute to H2O2-induced brain dysfunction. PMID: 25100596
    11. in mice that lack the alpha5 subunit gene (Gabra5-/-), cultured embryonic hippocampal pyramidal neurons and ex vivo CA1 hippocampal neurons unexpectedly exhibited a decrease in Ih current density PMID: 23516534
    12. alpha5GABA(A) receptor activity increases during inflammation and that this increase is critical for inflammation-induced memory deficits. PMID: 22999935
    13. Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide. PMID: 22677273
    14. Data suggest that chronic exposure to ketamine impairs working memory in mice, which may be explained at least partly by up-regulation of Gabra5 subunits in the prefrontal cortex. PMID: 21712993
    15. the results of this study suggested that the alpha5-subunit containing gamma-aminobutyric acid subtype A receptors are not direct targets for positive modulation by ethanol nor do they contribute to ethanol-induced memory loss. PMID: 21070817
    16. Findings identify in alpha5(H105R) knockin mice a behavioral-cognitive phenotype affecting basal locomotion and the memory for location of objects indicative of hippocampal dysfunction resulting from moderately decreased alpha5-subunit contents. PMID: 20180861
    17. under specific conditions, alpha5GABA(A)R activity predominates over synaptic inhibition in modifying the strength of both synaptic plasticity in vitro and certain forms of memory in vivo PMID: 20392949
    18. These results show that alpha5GABA(A)R-mediated phasic inhibition is activated by the Schaffer collateral pathway and provide evidence for activity pattern-dependent participation of alpha5GABA(A)Rs in inhibition. PMID: 19941877
    19. Enhanced learning and memory and altered GABAergic synaptic transmission in knockout mice PMID: 12097508
    20. tonic inhibition mediated by alpha5GABA(A)Rs in hippocampal pyramidal neurons plays a key role in cognitive processes PMID: 14993607
    21. The manifestation of tolerance to the sedative action of diazepam is associated with alpha5-GABA(A) receptor downregulation in the dentate gyrus. Chronic activation of alpha(5)-GABA(A) receptors is crucial for normal development of diazepam tolerance. PMID: 15282283
    22. Tonic inhibitory conductance in hippocampal pyramidal neurons generated by alpha5 subunit-containing GABA(A) receptors is highly sensitive to low concentrations of the volatile anesthetic isoflurane. PMID: 15456818
    23. A partial loss of hippocampal alpha 5 GABA(A) receptors is sufficient to alter one major form of selective learning. PMID: 17638582
    24. shunting inhibition mediated by alpha5GABA(A) receptors regulates the firing of action potentials and may synchronize network activity that underlies hippocampal-dependent behavior PMID: 17715197
    25. Depending on cell type, Gabra5 and delta subunits are the principal GABA A receptor subunits regulating tonic inhibition in hippocampal neurons. PMID: 18256262
    26. These findings imply an important role of histidine 105 in determining the position of the alpha5 subunit within the receptor complex by determining the affinity for assembly with the gamma2 subunit. PMID: 19457072

    显示更多

    收起更多

  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA5 sub-subfamily
  • 数据库链接：

    KEGG: mmu:110886

    STRING: 10090.ENSMUSP00000063276

    UniGene: Mm.273114