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  4. Recombinant Mouse Group IIF secretory phospholipase A2 (Pla2g2f)

Recombinant Mouse Group IIF secretory phospholipase A2 (Pla2g2f)

  • 中文名称：
    小鼠Pla2g2f重组蛋白
  • 货号：
    CSB-YP889911MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pla2g2f重组蛋白
  • 货号：
    CSB-EP889911MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pla2g2f重组蛋白
  • 货号：
    CSB-EP889911MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pla2g2f重组蛋白
  • 货号：
    CSB-BP889911MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pla2g2f重组蛋白
  • 货号：
    CSB-MP889911MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Pla2g2f; Group IIF secretory phospholipase A2; GIIF sPLA2; sPLA2-IIF; EC 3.1.1.4; Phosphatidylcholine 2-acylhydrolase 2F
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-168
  • 氨基酸序列
    SLLNLKSMVE AITHRNSILS FVGYGCYCGL GGRGHPMDEV DWCCHAHDCC YEKLFEQGCR PYVDHYDHRI ENGTMIVCTE LNETECDKQT CECDKSLTLC LKDHPYRNKY RGYFNVYCQG PTPNCSIYDP YPEEVTCGHG LPATPVST
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines. May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases.
  • 基因功能参考文献：
    1. Ethanolamine lysoplasmalogen, a PLA2G2F-derived marker product, rescued defective activation of Pla2g2f(-/-) keratinocytes both in vitro and in vivo PMID: 26438362
    2. SKH2/J pigmented mice display enhanced expression of the stratum corneum acidifying enzyme, secretory phospholipase A2f (sPLA2f). PMID: 24732399
    3. two of these isoforms, sPLA2 IIA and sPLA2 IIF, localize to the upper stratum granulosum and increase in response to experimental barrier perturbation. PMID: 24269828
  • 亚细胞定位：
    Secreted. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Phospholipase A2 family
  • 组织特异性：
    Strongly expressed in testis.
  • 数据库链接：

    KEGG: mmu:26971

    STRING: 10090.ENSMUSP00000030526

    UniGene: Mm.331989