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  4. Recombinant Mouse Homeobox protein Hox-B8 (Hoxb8)

Recombinant Mouse Homeobox protein Hox-B8 (Hoxb8)

  • 中文名称：
    小鼠Hoxb8重组蛋白
  • 货号：
    CSB-YP010668MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hoxb8重组蛋白
  • 货号：
    CSB-EP010668MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hoxb8重组蛋白
  • 货号：
    CSB-EP010668MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hoxb8重组蛋白
  • 货号：
    CSB-BP010668MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hoxb8重组蛋白
  • 货号：
    CSB-MP010668MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxb8
  • Uniprot No.：
  • 别名：
    Hoxb8; Hox-2.4; Hoxb-8Homeobox protein Hox-B8; Homeobox protein Hox-2.4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-243
  • 氨基酸序列
    MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK WKKENNKDKF PSSKCEQEEL EKEKLERAPE TAEQGDAQKG DKK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. Production and Functional Characterization of Murine Osteoclasts Differentiated from ER-Hoxb8-Immortalized Myeloid Progenitor Cells PMID: 26529319
    2. results demonstrate an important role for the intersection of Lmx1b and Hoxb8::cre expression in the development of nociceptive dorsal horn circuits critical for mechanical and thermal pain processing. PMID: 25834049
    3. Results show a previously unrecognised link between Hoxb8 expression and microRNAs that provides a new insight into the oncogenic functions of Hoxb8. PMID: 23872792
    4. Mouse Hoxb8 mutants show unexpected behavior manifested by compulsive grooming and hair removal further, transplantation of wild-type bone marrow into Hoxb8 mutant mice rescues their pathological phenotype. PMID: 20510925
    5. Data sugest that cooperative binding between Hoxb8 hexapeptide motif and cofactors is a critical element in the fine-tuning of Hoxb8 protein target specificity. PMID: 14623233
    6. RNA fragments diagnostic of miR-196-directed cleavage of HOXB8 were detected in mouse embryos; results point to a miRNA-mediated mechanism for the posttranscriptional restriction of HOX gene expression during vertebrate development PMID: 15105502
    7. Hoxb8 inhibited the activity of the telokin, SM22alpha, and smooth muscle alpha-actin promoters PMID: 15886193
    8. miR-196 acts upstream of Hoxb8 and Sonic hedgehog (Shh) in vivo in the context of limb development, thereby identifying a previously observed but uncharacterized inhibitory activity that operates specifically in the hindlimb PMID: 16319892
    9. Results indicate distinct roles for class 2 Polycomb group complexes in transcriptionally repressed and active domains of Hoxb8 gene. PMID: 16687444
    10. These results suggest that miR-196 participates in myeloid differentiation of HL60 cells via regulation of HOXB8 expression. PMID: 17150553
    11. A lower number of neurons in the upper spinal laminae and neuronal disorganization in the dorsal horn underlie the sensory defects including the excessive grooming of the Hoxb8 mutant. PMID: 18430798

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    KEGG: mmu:15416

    STRING: 10090.ENSMUSP00000052496

    UniGene: Mm.4822