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  4. Recombinant Mouse Hyaluronidase-1 (Hyal1)

Recombinant Mouse Hyaluronidase-1 (Hyal1)

  • 中文名称：
    小鼠Hyal1重组蛋白
  • 货号：
    CSB-YP835606MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hyal1重组蛋白
  • 货号：
    CSB-EP835606MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hyal1重组蛋白
  • 货号：
    CSB-EP835606MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hyal1重组蛋白
  • 货号：
    CSB-BP835606MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hyal1重组蛋白
  • 货号：
    CSB-MP835606MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hyal1
  • Uniprot No.：
  • 别名：
    Hyal1Hyaluronidase-1; Hyal-1; EC 3.2.1.35; Hyaluronoglucosaminidase-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    53-462
  • 氨基酸序列
    SVVSNRPF ITVWNGDTHW CLTEYGVDVD VSVFDVVANK EQSFQGSNMT IFYREELGTY PYYTPTGEPV FGGLPQNASL VTHLAHTFQD IKAAMPEPDF SGLAVIDWEA WRPRWAFNWD SKDIYRQRSM ELVQAEHPDW PETLVEAAAK NQFQEAAEAW MAGTLQLGQV LRPRGLWGYY GFPDCYNNDF LSLNYTGQCP VFVRDQNDQL GWLWNQSYAL YPSIYLPAAL MGTEKSQMYV RHRVQEALRV AIVSRDPHVP VMPYVQIFYE MTDYLLPLEE LEHSLGESAA QGVAGAVLWL SSDKTSTKES CQAIKAYMDS TLGPFIVNVT SAALLCSEAL CSGHGRCVRH PSYPEALLTL NPASFSIELT HDGRPPSLKG TLSLKDRAQM AMKFRCRCYR GWRGKWCDKR GM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
  • 基因功能参考文献：
    1. It was concluded that: HYAL1 and HYAL2 are both needed for tissue HA catabolism; 2) HYAL2 is required for high MW HA clearance in lymph nodes and plasma and for HA endocytosis by liver NPCs; and 3) the main role of HYAL1 is HA degradation within liver NPCs. PMID: 26887442
    2. Findings suggest that HYAL1 contributes to endothelial and glycocalyx dysfunction induced by diabetes. HYAL1 inhibitors could be explored as a new therapeutic approach to prevent vascular complications in diabetes. PMID: 27246914
    3. HYAL1 is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 is essential for the degradation of extracellular HA in all kidney regions PMID: 25468725
    4. The activity of the processed form of Hyal-1 was largely underestimated. PMID: 24502338
    5. The knockdown of Hyal-1 results in an 80% decrease of total acid hyaluronidase activity in the mouse liver, confirming that Hyal-1 is a key actor of hyaluronic acid catabolism in this organ. PMID: 24667601
    6. Chondroitin sulfate is a crucial determinant for skeletal muscle development/regeneration and improvement of muscular dystrophies through HYAL1 PMID: 23007393
    7. both HYAL1 and beta-hexosaminidase cleave chondroitin sulfate, but it is a preferred substrate for beta-hexosaminidase. These studies provide in vivo evidence to support and extend existing knowledge of GAG breakdown. PMID: 22451654
    8. Data show that Hyal-1, but not Hyal-3,is an ovarian regulator factor for follicle development, and show an interrelationship between this enzyme and the follistatin/activin/Smad3 pathway. PMID: 21732362
    9. Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice PMID: 21170388
    10. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. PMID: 11929860
    11. Hyal1 null mice had evidence of osteoarthritis with a loss of proteoglycans at early ages. PMID: 18344557
    12. Hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia. PMID: 18653706

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  • 亚细胞定位：
    Secreted. Lysosome.
  • 蛋白家族：
    Glycosyl hydrolase 56 family
  • 组织特异性：
    Highly expressed in liver, kidney, lung and skin.
  • 数据库链接：

    KEGG: mmu:15586

    STRING: 10090.ENSMUSP00000010195

    UniGene: Mm.475658