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  4. Recombinant Mouse Interleukin-17 receptor D (Il17rd), partial

Recombinant Mouse Interleukin-17 receptor D (Il17rd), partial

  • 中文名称：
    小鼠Il17rd重组蛋白
  • 货号：
    CSB-YP815627MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Il17rd重组蛋白
  • 货号：
    CSB-EP815627MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Il17rd重组蛋白
  • 货号：
    CSB-EP815627MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Il17rd重组蛋白
  • 货号：
    CSB-BP815627MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Il17rd重组蛋白
  • 货号：
    CSB-MP815627MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Il17rd
  • Uniprot No.：
  • 别名：
    Il17rd; Il17rlm; Sef; Interleukin-17 receptor D; IL-17 receptor D; IL-17RD; Interleukin-17 receptor-like protein; Sef homolog; mSef
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK. Mediates JNK activation and may be involved in apoptosis. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Might have a role in the early stages of fate specification of GnRH-secreting neurons. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
  • 基因功能参考文献：
    1. Deficiency of IL-17RD expression in cells leads to enhanced pro-inflammatory signalling and gene expression in response to TLR stimulation, and Il17rd(-/-) mice are more susceptible to TLR-induced septic shock. PMID: 25808990
    2. Demonstrate SEF expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms. PMID: 25118304
    3. these studies indicate that Sef has specific roles in osteoblast and osteoclast lineages and that its absence results in increased osteoblast and osteoclast activity with a net increase in cortical bone mass. PMID: 24127237
    4. Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia. PMID: 23047677
    5. Since expression of IL-17 is elevated in 3-month-old MRL/lpr mice, we suggest that it plays a role in the pathophysiology of autoimmune dacryoadenitis in these mice. PMID: 20858106
    6. Over-expressing Sef specifically in the lens of transgenic mice led to impaired lens and eye development that resulted in microphthalmia. PMID: 20542628
    7. Fgf8, Spry2 and Sef belong to a synexpression group and may functionally interact during mouse embryonic development PMID: 11960706
    8. Sef exerts its inhibitory effects at the level of FGFR and upstream of Ras providing an additional level of negative regulation of FGF signaling PMID: 12604616
    9. Sef and Sproutys function synergistically to regulate Gbx2 expression in the anterior hindbrain. PMID: 15729686
    10. Here we demonstrated that both extracellular and transmembrane domains of Sef contributed to Sef-mediated negative regulation of FGF signaling. PMID: 16603339
    11. Sef-S inhibits FGF-induced NIH3T3 cell proliferation via an ERK-independent mechanism and therefore suggest that alternative splice licenses sef gene to inhibit cell proliferation via multiple signaling pathways. PMID: 16857343
    12. Sef is expressed in the lens throughout embryogenesis and becomes restricted to the lens epithelium, indicating that lens cell proliferation and fiber differentiation may be tightly regulated by this negative regulatory molecule. PMID: 17141539
    13. These results show both increases and decreases in Sef levels affect the assembly and function of the auditory brainstem. PMID: 17442811
    14. Sef (Il17rd) interacts with TAK1 and mediates JNK activation and apoptosis. PMID: 15277532

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
  • 数据库链接：

    KEGG: mmu:171463

    STRING: 10090.ENSMUSP00000036076

    UniGene: Mm.206726