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  4. Recombinant Mouse Kin of IRRE-like protein 1 (Kirrel), partial

Recombinant Mouse Kin of IRRE-like protein 1 (Kirrel), partial

  • 中文名称：
    小鼠Kirrel1重组蛋白
  • 货号：
    CSB-YP772153MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Kirrel1重组蛋白
  • 货号：
    CSB-EP772153MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Kirrel1重组蛋白
  • 货号：
    CSB-EP772153MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Kirrel1重组蛋白
  • 货号：
    CSB-BP772153MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Kirrel1重组蛋白
  • 货号：
    CSB-MP772153MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Kirrel1
  • Uniprot No.：
  • 别名：
    Kirrel1; Kirrel; Neph1Kin of IRRE-like protein 1; Kin of irregular chiasm-like protein 1; Nephrin-like protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
  • 基因功能参考文献：
    1. KIRREL was overexpressed in gastric cancer. PMID: 29717104
    2. Here we demonstrate that Neph1, Neph2, and Neph3 are expressed differentially in various tissues during ontogenesis in mouse and chicken. PMID: 22205279
    3. Analysis of five promoter-reporter gene constructs showed that regulatory elements driving expression encoded by exon 1A in kidney and brain are localized in region between -4 kb and 2.1 kb. PMID: 12538735
    4. Fyn catalyzes Nephrin phosphorylation in podocyte detergent-resistant membrane fractions. PMID: 12668668
    5. nephrin and Neph1 interact and have roles in glomerular permeability PMID: 12865409
    6. In the adult brain, Neph1 is seen in the olfactory nerve layer and the glomerular layer of the olfactory bulb, in the hippocampus, and in cerebellar Purkinje cells. At the ultrastructural level, Neph1 is seen in dendritic shafts of pyramidal neurons. PMID: 16874800
    7. Nephrin-Neph1 complex transduces phosphorylation-mediated signals that assemble an actin polymerization complex at the podocyte intercellular junction. PMID: 17923684

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Note=Predominantly located at podocyte slit diaphragm.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 组织特异性：
    Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
  • 数据库链接：

    KEGG: mmu:170643

    STRING: 10090.ENSMUSP00000103243

    UniGene: Mm.89552