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  4. Recombinant Mouse Major histocompatibility complex class I-related gene protein (Mr1), partial

Recombinant Mouse Major histocompatibility complex class I-related gene protein (Mr1), partial

  • 中文名称：
    小鼠Mr1重组蛋白
  • 货号：
    CSB-YP818173MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mr1重组蛋白
  • 货号：
    CSB-EP818173MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mr1重组蛋白
  • 货号：
    CSB-EP818173MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mr1重组蛋白
  • 货号：
    CSB-BP818173MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mr1重组蛋白
  • 货号：
    CSB-MP818173MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mr1
  • Uniprot No.：
  • 别名：
    Mr1; Mr1a; Major histocompatibility complex class I-related gene protein; MHC class I-related gene protein; Class I histocompatibility antigen-like protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers. Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively. May present microbial antigens to various TRAV1-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells. During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora. Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR on a non-MAIT CD8-positive T cell clone, triggering T cell-mediated killing of a wide range of cancer cell types.
  • 基因功能参考文献：
    1. Here the s demonstrate that major histocompatibility complex class I deficiency results in significant dendritic atrophy along with an increase in thin dendritic spines and a reduction in stubby spines in the hippocampus of aged (12 month old) mice. PMID: 27229916
    2. MR1 tetramers allow precise phenotypic characterization of human and mouse mucosal-associated invariant T cells. PMID: 24101382
    3. differential contribution of particular amino acids to the MAIT TCR-MR1 interaction based upon the presence of bacteria PMID: 23342002
    4. The results of this study supported that MHCI appears to differentially modulate neuritogenesis and synaptogenesis. PMID: 22503373
    5. Data suggest that constitutive expression of MR1 may be detrimental for maintenance of immune homeostasis in the gut and/or detection of pathogenic bacteria in mucosal tissues. PMID: 21402896
    6. The study demonistrated that the enhanced neuronal MHCI expression as a beneficial factor for promoting recovery of locomotor function after spinal cord injury. PMID: 21259323
    7. fact that MR1 seems mainly intracellular might offer clues as to the process, given the precedence in other class I molecules PMID: 21190736
    8. Gene silencing of myofibrillogenesis regulator-1 by adenovirus-delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice. PMID: 20802139
    9. MR1 protein can associate with beta(2)-microglobulin PMID: 11785959
    10. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1 PMID: 12634786
    11. Analysis of murine MR1 expressed in a murine cell line reveals that MR1 associates with the peptide-loading complex, indicating that MR1 uses the same cellular assembly machinery as do classical class I molecules. PMID: 12794138
    12. MR1 has an antigen presentation function PMID: 15802267
    13. HA peptides are expressed by EGCs and recognized by CD8 T cells that express a T-cell receptor (TCR) specific for Kd:HA512-520 (CL4) or CD4 T cells that express a TCR specific for IEd:HA107-119 (6.5), respectively. PMID: 18395084
    14. MR1 traffics through endocytic compartments, thereby allowing mucosal-associated invariant T cells to sample both endocytosed and endogenous antigens. PMID: 18443227
    15. the presentation pathway of MR1 to MAIT cells is highly evolutionarily conserved PMID: 19416870

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    MHC class I family
  • 组织特异性：
    Highly expressed thymus. Expressed in liver, kidney, spleen, heart, brain, lung, skeletal muscle and testis.
  • 数据库链接：

    KEGG: mmu:15064

    STRING: 10090.ENSMUSP00000027744

    UniGene: Mm.7580