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  4. Recombinant Mouse Meckel syndrome type 1 protein homolog (Mks1)

Recombinant Mouse Meckel syndrome type 1 protein homolog (Mks1)

  • 中文名称：
    小鼠Mks1重组蛋白
  • 货号：
    CSB-YP722551MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mks1重组蛋白
  • 货号：
    CSB-EP722551MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mks1重组蛋白
  • 货号：
    CSB-EP722551MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mks1重组蛋白
  • 货号：
    CSB-BP722551MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mks1重组蛋白
  • 货号：
    CSB-MP722551MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mks1
  • Uniprot No.：
  • 别名：
    Mks1Meckel syndrome type 1 protein homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-561
  • 氨基酸序列
    MAEAVWSTDT GEAVYRSRDP VRNLRLRVHL QRITSSNFLH YQPAAQMGKD LIDLATFRPP QAASGHRPDE EEEEEVVIGW QEKLFSQFEV DLYQNESACQ SPLDHQYRQE ILKLENSGGR KNRRIFTYTD SDRYTDLEEY CQKITTSASE VPSFLAERMA NVRRRRQDRR GVEGSKLKSR IVTWEPSEDF IKNNHAINTP LQTMYIMADL GPYGKLGYKV HEHVLCILKV DSNGVITVKP DFTGIKGPYR IETEGEKQEH TSAWKYTIDN VSSLAQPEEE EREQRVFKDL YGRHKEYLSS LVGTDFEMIA PGALRLFVNG EVVSAQGYEY DNLYVHFFVE LPAANWSSPP FQQLSGVTQA CATKSLGMDK VAYFSFPFTF EAFFLHEDES AESLPEWPVL YCKVLSLDFW QRYRVEGYGA VVLPATPGSH TLTVSTWRPM ELGLVAELRR FFIGGSLELE DPSYVRIPGT FKGERLSRFG FRTETTGTVT FRLHCLQQSR AFMESNSLQK QMRSVLDRLE GFSQQSSTHN VLEAFRRARR RMQEARESLP QDLVSPTGTL T
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.
  • 基因功能参考文献：
    1. Dnah11(avc)(4) did not disrupt SHF Hh signaling and caused Atrioventricular septal defects (AVSDs) only concurrently with heterotaxy, a left/right axis abnormality. In contrast, Mks1(avc)(6) disrupted SHF Hh signaling and caused AVSDs without heterotaxy.We speculate that cilia gene mutations contribute to both syndromic and non-syndromic AVSDs in humans PMID: 27340223
    2. Centriole localization of Mks1 is required for ciliogenesis of motile and non-motile cilia, but not for centriole assembly. PMID: 21045211
    3. Mks1 is required for ciliogenesis and shh signaling in mouse model of human meckel syndrome. PMID: 19776033
    4. Mks1 expression in mouse embryos, as determined by in situ hybridization, agrees well with the tissue phenotype of MKS. PMID: 16415886
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.
  • 组织特异性：
    Widely expressed in embryo at E15.5, with a relatively strong expression in brain, liver, kidney and digits of the upper limbs. Highly expressed in bronchiolar epithelium.
  • 数据库链接：

    KEGG: mmu:380718

    STRING: 10090.ENSMUSP00000043790

    UniGene: Mm.24404