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  4. Recombinant Mouse Meiotic recombination protein DMC1/LIM15 homolog (Dmc1)

Recombinant Mouse Meiotic recombination protein DMC1/LIM15 homolog (Dmc1)

  • 中文名称：
    小鼠Dmc1重组蛋白
  • 货号：
    CSB-YP730756MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dmc1重组蛋白
  • 货号：
    CSB-EP730756MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dmc1重组蛋白
  • 货号：
    CSB-EP730756MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dmc1重组蛋白
  • 货号：
    CSB-BP730756MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dmc1重组蛋白
  • 货号：
    CSB-MP730756MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dmc1
  • Uniprot No.：
  • 别名：
    Dmc1; Dmc1h; Lim15Meiotic recombination protein DMC1/LIM15 homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-340
  • 氨基酸序列
    MKEDQVVQEE SGFQDDEESL FQDIDLLQKH GINMADIKKL KSVGICTIKG IQMTTRRALC NVKGLSEAKV EKIKEAANKL IEPGFLTAFQ YSERRKMVFH ITTGSQEFDK LLGGGIESMA ITEAFGEFRT GKTQLSHTLC VTAQLPGTGG YSGGKIIFID TENTFRPDRL RDIADRFNVD HEAVLDNVLY ARAYTSEHQM ELLDYVAAKF HEEAGIFKLL IIDSIMALFR VDFSGRGELA ERQQKLAQML SRLQKISEEY NVAVFVTNQM TADPGATMTF QADPKKPIGG HILAHASTTR ISLRKGRGEL RIAKIYDSPE MPENEATFAI TAGGIGDAKE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
  • 基因功能参考文献：
    1. The DMC1 was highly variable from cell to cell, whereas foci of the crossover marker MLH1 showed little variability. PMID: 22388890
    2. RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes. PMID: 21307306
    3. p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells PMID: 14764457
    4. TBPIP/HOP2 directly binds to DNA and functions as an activator for DMC1 during the homologous pairing step in meiosis PMID: 15192114
    5. data reveal an interplay among Hop2, Mnd1 and Rad51 and Dmc1 in the formation of the first recombination intermediates during meiosis PMID: 15834424
    6. Mei1 can be positioned upstream of Dmc1 in the genetic pathway that operates during mammalian meiosis PMID: 15928951
    7. Dmc1(Mei11) exposes a sex difference in recombination in that a significant portion of female oocytes can compensate for DMC1 deficiency to undergo crossing-over and complete gametogenesis. PMID: 17425408

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    RecA family, DMC1 subfamily
  • 组织特异性：
    Testis.
  • 数据库链接：

    KEGG: mmu:13404

    STRING: 10090.ENSMUSP00000023065

    UniGene: Mm.2524