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  4. Recombinant Mouse Metastasis suppressor protein 1 (Mtss1)

Recombinant Mouse Metastasis suppressor protein 1 (Mtss1)

  • 中文名称：
    小鼠Mtss1重组蛋白
  • 货号：
    CSB-YP854498MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Mtss1重组蛋白
  • 货号：
    CSB-EP854498MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Mtss1重组蛋白
  • 货号：
    CSB-EP854498MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Mtss1重组蛋白
  • 货号：
    CSB-BP854498MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Mtss1重组蛋白
  • 货号：
    CSB-MP854498MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mtss1
  • Uniprot No.：
  • 别名：
    Mtss1; Mim; Protein MTSS 1; Metastasis suppressor protein 1; Missing in metastasis protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-254
  • 氨基酸序列
    MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQK VADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVAN QLDKDHAKEYKKARQEIKNKSSDTLKLQKKAKKVDAQGRGDIQPQLDSALQDVNDKYLLL EETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKL PSSSEQVILDLKGS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits the nucleation of actin filaments in vitro.
  • 基因功能参考文献：
    1. Mtss1 is a key linker between the actin cytoskeleton and the cell membrane, for the development and maintenance of a paradigmatic neuronal circuit, the cerebellar cortex. PMID: 28214917
    2. Study showed that MTSS1 regulates neurite outgrowth and dendritic arborization in primary neurons in vitro, possibly through a Rac1- and PIP-dependent pathway. PMID: 27401056
    3. role of MIM in the homeostasis of BM cells, including HSPCs, through modulation of the CXCR4/SDF-1 axis and interactions of BM leukocytes with their microenvironments. PMID: 26965284
    4. Identify the inverse-BAR (I-BAR) protein MIM/MTSS1 as a nucleator of dendritic spines. MIM accumulated to future spine initiation sites in a PIP2-dependent manner and deformed the plasma membrane outward into a proto-protrusion via its I-BAR domain. PMID: 26051541
    5. The data demonstrated for the first time an important role for missing-in-metastasis protein in B-cell development. There was a predisposition of missing-in-metastasis-null mice to develop diffuse large B lymphomas. PMID: 22081072
    6. MTSS1 might be involved in shaping neuronal membranes in vivo. PMID: 21651965
    7. endogenous MIM protein regulates globally the cell architecture and endocytosis that ultimately influence a variety of cellular behaviors, including cell polarity, motility, receptor signaling and membrane ruffling PMID: 21695258
    8. MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. PMID: 21406566
    9. Results suggest that MIM promotes ciliogenesis by antagonizing Src-dependent phosphorylation of Cortactin and describe a mechanism linking regulation of the actin cytoskeleton with ciliogenesis and Shh signaling during tissue regeneration. PMID: 20708589
    10. tissue-specific regulator of cytoskeletal dynamics that interacts with ATP-actin monomers through its C-terminal WH2 domain PMID: 12482861
    11. Hedgehog-responsive gene MIM cooperates with receptor protein tyrosine phosphatase-delta to induce cytoskeletal remodeling. PMID: 15684034
    12. Mtss1 represents a novel signaling pathway from PDGF receptor to the actin cytoskeleton via Src-related kinases. PMID: 17224454
    13. The crystal structures of MIM's IMD and that of its WH2 bound to actin was determined. PMID: 17292833
    14. potential role of Mtss1 for cytoskeletal dynamics in developing and mature cerebellar neurons PMID: 17925019

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    MTSS1 family
  • 组织特异性：
    Strongly expressed in the developing neurons and skeletal and cardiac muscles in embryos. Strongly expressed also in liver, outer layers of the kidney, and in the Purkinje cells of the brain.
  • 数据库链接：

    KEGG: mmu:211401

    STRING: 10090.ENSMUSP00000079239

    UniGene: Mm.215481