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  4. Recombinant Mouse Monocarboxylate transporter 8 (Slc16a2), partial

Recombinant Mouse Monocarboxylate transporter 8 (Slc16a2), partial

  • 中文名称：
    小鼠Slc16a2重组蛋白
  • 货号：
    CSB-YP021409MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Slc16a2重组蛋白
  • 货号：
    CSB-EP021409MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Slc16a2重组蛋白
  • 货号：
    CSB-EP021409MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Slc16a2重组蛋白
  • 货号：
    CSB-BP021409MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Slc16a2重组蛋白
  • 货号：
    CSB-MP021409MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc16a2
  • Uniprot No.：
  • 别名：
    Slc16a2; Mct8; Xpct; Monocarboxylate transporter 8; MCT 8; Solute carrier family 16 member 2; X-linked PEST-containing transporter
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr.
  • 基因功能参考文献：
    1. An essential physiological requirement for MCT8 in chondrocytes, and a role for additional transporters in other skeletal cells during adult bone maintenance. PMID: 28637283
    2. The marked phenotypic abnormalities observed in the D3-deficient mouse, including perinatal mortality, growth retardation, and central hypothyroidism in adult animals, require expression of MCT8, confirming the interdependent relationship between the TH transport into cells and the deiodination processes. PMID: 27254003
    3. Data indicate silymarin, an extract of the milk thistle, to be a potent inhibitor of T3 thyroid hormone uptake by solute carrier family 16 (monocarboxylic acid transporters), member 2 protein (MCT8). PMID: 26910310
    4. Data show that diiodothyropropionic acid (DITPA) mainly ameliorated the hypermetabolism of monocarboxylate transporter 8 (MCT8) knockout mice. PMID: 26322373
    5. The data demonstrate that OATP1c1 and MCT8 expression are regulated in a parallel manner during inflammation at the blood-brain barrier of rodents. PMID: 25594699
    6. Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation. PMID: 24819605
    7. Mct8 deficiency has important metabolic consequences in the brain PMID: 24098341
    8. Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis. PMID: 24691440
    9. Mct10 participates in tissue-specific TH transport and also contributes to the generation of the unusual serum TH profile characteristic for Mct8 deficiency PMID: 24248460
    10. These studies indicate that the high serum T3 in MCT8 deficiency increases the total energy expenditure and fails to maintain weight despite adequate calorie intake. PMID: 24029243
    11. Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice. PMID: 23776477
    12. PBF is the first protein to interact with the critical TH transporter MCT8 and modulate its function in vivo PMID: 22535767
    13. While the new pairing element (Xpr), located ~200 kb upstream of Xist, in the Xpct region contains unusual properties, it most likely does not serve as a pairing or counting element. PMID: 21327163
    14. expression of candidate thyroid hormone transporters Lat1, Mct8, Mct10, and Oatp1c1 in mouse cochlear development PMID: 21878515
    15. The expression of Mct8 and L-type amino acid transporters Lat1 and Lat2 are determined in brain neurons during development; Lat2 and Mct8 participate in thyroid hormone transport into primary astrocytes PMID: 21264952
    16. These studies suggest that deiodinases contribute to increased triiodothyronine in Mct8 deficiency. PMID: 21285310
    17. Increased thyroidal T3 secretion in Mct8 ko mice represents an important pathogenic mechanism leading to the high serum T3 levels. PMID: 20702572
    18. Retinoic acid induces expression of the thyroid hormone transporter, monocarboxylate transporter 8 (Mct8). PMID: 20573951
    19. Data show that combined disruption of Mct8 and Dio2 led to similar effects as hypothyroidism on the expression of 24 genes. PMID: 20211971
    20. Enhanced uptake and accumulation of thyroxine in the kidneys of MCT8 null mice contributes to low serum thyroxine and increased blood triiodothyronine. PMID: 19996182
    21. Energy metabolism in the context of Sertoli cell-germ cell metabolic cooperation where lactate is produced in somatic cells and transported to germ cells occurs via monocarboxylate transporters. PMID: 12773420
    22. Recent findings obtained by analyzing MCT8 ko animals. PMID: 17574008
    23. MCT8 expression was coincident with that of neural stem cell markers, and the overexpression of MCT8 accelerated the differentiation into neural cells PMID: 17624308
    24. Data report here that in addition to neuronal expression, MCT8 mRNA and protein are expressed in cerebral microvessels in mouse. PMID: 18687783
    25. the pattern of MCT8 expression observed in vivo and in vitro suggests that MCT8 may be important to modulate thyroid hormone effects on osteoblast differentiation and on bone development and metabolism. PMID: 19133747
    26. The main restriction for T(3) entry into the neural target cells of the mouse deficient in Mct8 is at the blood-brain barrier. PMID: 19147674
    27. lack of functional complementation by alternative thyroid hormone transporters in developing human neurons precipitates the neurodevelopmental phenotype in MCT8-deficiencies; Mct8-deficient mouse neurons are functionally complemented by other transporters PMID: 19641107

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Monocarboxylate porter (TC 2.A.1.13) family
  • 组织特异性：
    Highly expressed in liver and kidney.
  • 数据库链接：

    KEGG: mmu:20502

    STRING: 10090.ENSMUSP00000037629

    UniGene: Mm.388973