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  4. Recombinant Mouse N-acetylmuramoyl-L-alanine amidase (Pglyrp2)

Recombinant Mouse N-acetylmuramoyl-L-alanine amidase (Pglyrp2)

  • 中文名称：
    小鼠Pglyrp2重组蛋白
  • 货号：
    CSB-YP837705MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pglyrp2重组蛋白
  • 货号：
    CSB-EP837705MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pglyrp2重组蛋白
  • 货号：
    CSB-EP837705MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pglyrp2重组蛋白
  • 货号：
    CSB-BP837705MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pglyrp2重组蛋白
  • 货号：
    CSB-MP837705MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pglyrp2
  • Uniprot No.：
  • 别名：
    Pglyrp2; Pglyrpl; Pgrpl; N-acetylmuramoyl-L-alanine amidase; EC 3.5.1.28; Peptidoglycan recognition protein 2; Peptidoglycan recognition protein long; PGRP-L; TagL
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-530
  • 氨基酸序列
    SSLPLLMD SIIQALAELE QKVPVTEASI TASAWILSAK NSSTHNSLHQ RLLLKAPSHN TTEPDPHSLS PELQALISEV AQHDVQNGRE YGVVLAPDGS TVAVKPLLFG LEAGLQAHSV ANLPSDCLAI PCDTGDTLAN IRATWPGLMD AFPNASSPDV GATLPNDKAK TPTTVDRLLA ITLAGDLGLT FLHRSQTWSP PGLGTEGCWD QLTAPRVFTL LDPQASRLTM AFLNGALDGA LLGNHLSQIP RPHPPLSHLL REYYGAGVNG DPVFRSNFRR QNGAALTSAP TLAQQVWEAL VLLQKLEPEH LQLQNISQEQ LAQVATLATK EFTEAFLGCP AIHPRCRWGA APYRGHPTPL RLPLGFLYVH HTYVPAPPCT TFQSCAADMR SMQRFHQDVR KWDDIGYSFV VGSDGYLYQG RGWHWVGAHT RGYNSRGFGV AFVGNYTGSL PNEAALNTVR DALPSCAIRA GLLRPDYKLL GHRQLVLTHC PGNALFNLLR TWPHFTEVEN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.
  • 基因功能参考文献：
    1. Study shows sex-dependent alterations in motor and anxiety-like behavior of aged bacterial peptidoglycan sensing molecule 2 (Pglyrp2) knockout mice. The findings suggest a novel role for Pglyrp2 as a key regulator of motor and anxiety-like behavior in late life. PMID: 28951252
    2. Pglyrp-2 expression was induced after infection in WT mice. Pglyrp-3 expression was low before and after infection in WT mice, while Pglyrp-4 expression was slightly elevated after infection in WT, Pglyrp-2 and -3 null mice PMID: 26332373
    3. Nod2(-/-) Pglyrp2(-/-) mice displayed increased susceptibility to infection at 24 h postinfection compared to Pglyrp2(-/-). Thus, PGLYRP2 plays a protective role in vivo in the control of S. Typhimurium infection through a Nod1/Nod2-independent mechanism. PMID: 22615249
    4. Pglyrp2 limits overactivation of Th17 cells by promoting accumulation of regulatory T cells at the site of inflammation in an experimentally induced mouse model of psoriasis PMID: 22048773
    5. role in regulation of the enteric host-microbe homeostasis PMID: 20980996
    6. In contrast to its critical role in immunity in flies, PGRP-L is largely dispensable for mammalian immunity against bacteria and fungi. PMID: 15340057
    7. substantially impaired Listeria monocytogenes invasion and early intracellular growth in human epithelial cells. [TagL] PMID: 16487310
    8. The s demonstrate that PGLYRP-2 and Nod2 are both required for arthritis in the peptidoglycan-induced arthritis model in mice. PMID: 19218085

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  • 亚细胞定位：
    Secreted. Membrane.
  • 蛋白家族：
    N-acetylmuramoyl-L-alanine amidase 2 family
  • 组织特异性：
    Strongly expressed in liver and fetal liver.
  • 数据库链接：

    KEGG: mmu:57757

    STRING: 10090.ENSMUSP00000110099

    UniGene: Mm.86752