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  4. Recombinant Mouse N-acetyltransferase ESCO2 (Esco2)

Recombinant Mouse N-acetyltransferase ESCO2 (Esco2)

  • 中文名称：
    小鼠Esco2重组蛋白
  • 货号：
    CSB-YP815879MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Esco2重组蛋白
  • 货号：
    CSB-EP815879MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Esco2重组蛋白
  • 货号：
    CSB-EP815879MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Esco2重组蛋白
  • 货号：
    CSB-BP815879MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Esco2重组蛋白
  • 货号：
    CSB-MP815879MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Esco2
  • Uniprot No.：
  • 别名：
    Esco2N-acetyltransferase ESCO2; EC 2.3.1.-; Establishment of cohesion 1 homolog 2; ECO1 homolog 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-592
  • 氨基酸序列
    MMATCTPRKR KRYTLNADND DSLLTDISSS KLRCAENLFP SPNKKHNYQS SVQKEDKSCS HQLHFPSSPL KTTENSRFSF ANHSSLFKPA MSTVSFYSKE KYYLNPLERK LIRECRSICL ATESGDKPIP SVTENIQRKP VCTKKNKKKQ KSLTAKYQPN YKHIKSKSRN LKNSKPNQVT YKPVVDQENS CFPAKNYPNS PPRVLSQKIK PQVTLQGGAA FFVRKRNSLK KLPLEDKPLL LQKNLPEVPE GAPEAKQIPK SLLVDEKSSV KVQNARSKNE EKLRKNPSGA VVSSKECNLD KHDFPSENSL DENKTISPES VYPIFNVSSV NTKRPEEQSS VGSTACTNFL KQTNVPKNIN SRDTNKGGKD QLVIDAGQKH FGTTVCKSCG MIYTASNPED EIQHLQHHHR FLEGIKFVGW KRERVVAEFW DGKIVLVLPR DPSYAIKKVE DVQELVDLEL GFQQTVPVCP DKTKTFLFID EKRVVGCLIA EPIKQAFRVL SEPSASKECS RAWRCSDVPE PAICGISRIW VFRLKRRKRI ARRLVDTVRN CFMFGCFLST NEIAFSDPTP DGKLFATKYC NTPNFLVYNF HN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3.
  • 基因功能参考文献：
    1. ESCO2 knockdown inhibits cell proliferation and induces apoptosis in gastric cancer cells. PMID: 29330052
    2. the involvement of Esco2 in spindle assembly checkpoint and kinetochore functions is mediated by its binding to histone H4 and acetylation of H4K16 both in vivo and in vitro PMID: 28934466
    3. To Roberts syndrome(RBS), mouse Esco2 turns out to be a cell viability factor, the absence of which results in severe chromosome segregation defects and apoptosis. PMID: 22614755
    4. ESCO2 may play a vital role in meiosis in both males and females. PMID: 22699483
    5. Esco2 is needed for cohesin acetylation in PCH and that this modification is required for the proper distribution of cohesin on mitotic chromosomes and for centromeric cohesion PMID: 22101327
    6. Esco2 promotes neuronal differentiation by repressing Notch signaling. PMID: 21777673

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Acetyltransferase family, ECO subfamily
  • 数据库链接：

    KEGG: mmu:71988

    STRING: 10090.ENSMUSP00000022613

    UniGene: Mm.249280