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  4. Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-3 (Chrna3), partial

Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-3 (Chrna3), partial

  • 中文名称：
    Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-3(Chrna3),partial,Yeast
  • 货号：
    CSB-YP848130MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-3(Chrna3),partial,Yeast
  • 货号：
    CSB-EP848130MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-3(Chrna3),partial,Yeast
  • 货号：
    CSB-EP848130MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-3(Chrna3),partial,Yeast
  • 货号：
    CSB-BP848130MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Neuronal acetylcholine receptor subunit alpha-3(Chrna3),partial,Yeast
  • 货号：
    CSB-MP848130MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Chrna3
  • Uniprot No.：
  • 别名：
    Chrna3; Neuronal acetylcholine receptor subunit alpha-3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能参考文献：
    1. Mechanoinsensitive ''silent'' nociceptors are characterized by the expression of the nicotinic acetylcholine receptor subunit alpha-3 (CHRNA3); the mechanically gated ion channel PIEZO2 mediates NGF-induced mechanosensitivity in these neurons. PMID: 29241539
    2. neuroinflammation is sufficient to provoke the decrease of a7 and a4b2 nAChRs, Ab42 accumulation and memory impairment in mice and a7(1-208) nAChR-specific antibodies can cause inflammation of the brain with symptoms typical for Alzheimer disease PMID: 25816313
    3. The present findings suggest that its thymic production and/or release are under cholinergic control involving nAChR containing the alpha3-subunit. PMID: 25105141
    4. Greater expression of Chrna3 is found in whole brain and dissected brain regions relevant to locomotor behavior in mice that are less sensitive to ethanol-induced stimulation compared to mice that are robustly stimulated. PMID: 18826434
    5. The results of this study demonstrated that hyperglycemia also interferes with the function of alpha3-containing nAChRs through Cys residues on the alpha3 subunit PMID: 20620869
    6. functional nicotinic ACh receptors are detected on stem and progenitor cells of fetal mouse cerebral cortex as early as embryonic day 10 PMID: 12438103
    7. alpha3beta2 nicotinic receptor has a role in regulating gene expression after tobacco exposure in oral epithelial cells PMID: 15681842
    8. Fast synaptic transmission in mammalian sympathetic ganlia requires alpha3 expression; in knockout mice, the preganglionic nerve forms synapses that appear morphologically normal and persist for several weeks. PMID: 16162937
    9. Reporter gene analysis demonstrated that this sequence, termed "alpha3 intron 5," inhibits the transcriptional activities of the alpha3 and beta4 subunit gene promoters PMID: 17504758
    10. Our results suggest that PrP(C) is a member of a multiprotein membrane complex participating in the formation and function of alpha3beta4 nAChR. PMID: 18279314

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-3/CHRNA3 sub-subfamily
  • 数据库链接：

    KEGG: mmu:110834

    STRING: 10090.ENSMUSP00000034851

    UniGene: Mm.63569