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  4. Recombinant Mouse PDZ domain-containing protein GIPC3 (Gipc3)

Recombinant Mouse PDZ domain-containing protein GIPC3 (Gipc3)

  • 中文名称：
    小鼠Gipc3重组蛋白
  • 货号：
    CSB-YP851284MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Gipc3重组蛋白
  • 货号：
    CSB-EP851284MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Gipc3重组蛋白
  • 货号：
    CSB-EP851284MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Gipc3重组蛋白
  • 货号：
    CSB-BP851284MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Gipc3重组蛋白
  • 货号：
    CSB-MP851284MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gipc3
  • Uniprot No.：
  • 别名：
    Gipc3; Rgs19ip3; PDZ domain-containing protein GIPC3; Regulator of G-protein signaling 19-interacting protein 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-297
  • 氨基酸序列
    MDSAAPREPG ATEPPARARP RLVFRTQLAH GSPTGRIEGF TNVRELYAKI AEAFGIAPTE ILFCTLNSHK VDMQKLLGGQ IGLEDFIFAH VRGETKEVEV TKTEDALGLT ITDNGAGYAF IKRIKEGSII NRIEAVCVGD SIEAINDHSI VGCRHYEVAK MLRELPKSQP FTLRLVQPRR AFDMIGQRSR SSKCPVEAKV SSGRETLRLR SGGAATVEEA PSDVEAAAAR RVDDLLESYM GIRDPELAAA VVETARSSAG AQAFARGLDA VLGEFAFPDE FVVEVWAAIG EAHDACG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion.
  • 基因功能参考文献：
    1. the physiological significance of GIPC3 as a genetic interactor of BRCA2 is supported by the observation that Brca2-null embryos with Gipc3 overexpression are developmentally more advanced than their control littermates. Taken together, we have uncovered a novel role for GIPC3 as a BRCA2 genetic interactor. PMID: 29021281
    2. Gipc3 plays a pivotal role in acoustic signal acquisition and propagation in cochlear hair cells, while mutations are associated with audiogenic seizures and sensorineural hearing loss. PMID: 21326233
  • 相关疾病：
    Defects in GIPC3 underlie the age-related hearing loss 5 (ahl5) and juvenile audiogenic monogenic seizure (jams1) phenotypes. Ahl5 mice show irregular structure of the stereocilia bundle of outer and inner hair cells, late-onset degeneration of the organ of Corti. The spiral ganglion exhibits a severe loss of neurons.
  • 蛋白家族：
    GIPC family
  • 组织特异性：
    Expressed in adult lung, brain and testis. In the inner ear, it is expressed in the inner and outer hair cells of the organ of Corti. Also expressed in cochlear spiral ganglion neurons.
  • 数据库链接：

    KEGG: mmu:209047

    STRING: 10090.ENSMUSP00000049236

    UniGene: Mm.218755