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  4. Recombinant Mouse PEX5-related protein (Pex5l)

Recombinant Mouse PEX5-related protein (Pex5l)

  • 中文名称：
    小鼠Pex5l重组蛋白
  • 货号：
    CSB-YP804457MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Pex5l重组蛋白
  • 货号：
    CSB-EP804457MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Pex5l重组蛋白
  • 货号：
    CSB-EP804457MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Pex5l重组蛋白
  • 货号：
    CSB-BP804457MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Pex5l重组蛋白
  • 货号：
    CSB-MP804457MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pex5l
  • Uniprot No.：
  • 别名：
    Pex5l; Pex2; Pex5r; Pxr2; PEX5-related protein; PEX2-related protein; PEX5-like protein; Peroxin-5-related protein; Tetratricopeptide repeat-containing Rab8b-interacting protein; Pex5Rp; TRIP8b
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-567
  • 氨基酸序列
    MYQGHMQLVN EQQESRPLLS PSIDDFLCET KSEAIAKPVT SNTAVLTTGL DLLDLSEPVS QPQTKAKKSE PSSKSSSLKK KADGSDLISA DAEQRAQALR GPETSSLDLD IQTQLEKWDD VKFHGDRTSK GHLMAERKSC SSRTGSKELL WSAEHRSQPE LSTGKSALNS ESASELELVA PAQARLTKEH RWGSALLSRN HSLEEEFERA KAAVESDTEF WDKMQAEWEE MARRNWISEN QEAQNQVTVS ASEKGYYFHT ENPFKDWPGA FEEGLKRLKE GDLPVTILFM EAAILQDPGD AEAWQFLGIT QAENENEQAA IVALQRCLEL QPNNLKALMA LAVSYTNTSH QQDACEALKN WIKQNPKYKY LVKNKKGSPG LTRRMSKSPV DSSVLEGVKE LYLEAAHQNG DMIDPDLQTG LGVLFHLSGE FNRAIDAFNA ALTVRPEDYS LWNRLGATLA NGDRSEEAVE AYTRALEIQP GFIRSRYNLG ISCINLGAYR EAVSNFLTAL SLQRKSRNQQ QVPHPAISGN IWAALRIALS LMDQPELFQA ANLGDLDVLL RAFNLDP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.
  • 基因功能参考文献：
    1. Study characterized the effects of deletion of the HCN channel auxiliary subunit TRIP8b in the mouse thalamus and cortex, focusing on electrophysiological changes and their role in promoting absence epilepsy PMID: 26459112
    2. We conclude that TRIP8b in the retina is needed to achieve maximal expression of HCN1. PMID: 24409334
    3. TRIP8b deletion is not restricted to the integrative properties of neurons but also includes both synaptic and intrinsic plasticity PMID: 23966674
    4. TRIP8b isoforms are important regulators of HCN1 trafficking in entorhinal neurons. PMID: 22363812
    5. Study links elevated MMP-2/PEX2 to ischemia and poor wound healing. PMID: 21903356
    6. increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively. PMID: 21504900
    7. Mice lacking TRIP8b demonstrate motor learning deficits and enhanced resistance to multiple tasks of behavioral despair with high predictive validity for antidepressant efficacy. PMID: 21593326
    8. This study demonstrated that TRIP8b splice isoforms are necessary for the proper trafficking of HCN1 channels to the surface membrane of CA1 pyramidal neurons and for the proper targeting of the channels to the distal dendritic compartment. PMID: 21555075
    9. These data suggest a possible role for TRIP8b in regulating HCN channel density in the plasma membrane. [TRIP8b] PMID: 15564593
    10. Both untreated and bile acid-fed PEX2(-/-) mice accumulated high levels of predominantly unconjugated bile acids in plasma because of altered expression of hepatocyte bile acid transporters. PMID: 17393522
    11. The results suggested that all TRIP8b isoforms inhibit channel opening by shifting activation to more negative potentials. Its functions as an auxiliary subunit that provides a mechanism for the dynamic regulation of HCN1 channel expression and function. PMID: 19555649

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Peroxisomal targeting signal receptor family
  • 数据库链接：

    KEGG: mmu:58869

    STRING: 10090.ENSMUSP00000077353

    UniGene: Mm.151332