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  4. Recombinant Mouse Paired mesoderm homeobox protein 2B (Phox2b)

Recombinant Mouse Paired mesoderm homeobox protein 2B (Phox2b)

  • 中文名称：
    小鼠Phox2b重组蛋白
  • 货号：
    CSB-YP017941MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Phox2b重组蛋白
  • 货号：
    CSB-EP017941MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Phox2b重组蛋白
  • 货号：
    CSB-EP017941MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Phox2b重组蛋白
  • 货号：
    CSB-BP017941MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Phox2b重组蛋白
  • 货号：
    CSB-MP017941MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Phox2b
  • Uniprot No.：
  • 别名：
    Phox2b; Pmx2b; Paired mesoderm homeobox protein 2B; Neuroblastoma Phox; NBPhox; PHOX2B homeodomain protein; Paired-like homeobox 2B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-314
  • 氨基酸序列
    MYKMEYSYLN SSAYESCMAG MDTSSLASAY ADFSSCSQAS GFQYNPIRTT FGATSGCPSL TPGSCSLGTL RDHQSSPYAA VPYKLFTDHG GLNEKRKQRR IRTTFTSAQL KELERVFAET HYPDIYTREE LALKIDLTEA RVQVWFQNRR AKFRKQERAA AAAAAAAKNG SSGKKSDSSR DDESKEAKST DPDSTGGPGP NPNPTPSCGA NGGGGGGPSP AGAPGAAGPG GPGGEPGKGG AAAAAAAAAA AAAAAAAAAA GGLAAAGGPG QGWAPGPGPI TSIPDSLGGP FASVLSSLQR PNGAKAALVK SSMF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. This study demonstrated that the Phox2b distinguishes between oral and non-oral sensory neurons in the geniculate ganglion in mice. PMID: 28856690
    2. Murine models of congenital central hypoventilation syndrome designed with PHOX2B mutations have suggested RTN neuron agenesis. PMID: 27226447
    3. The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO2. PMID: 25866925
    4. Adult Phox2b(+/-) mice showed altered exploratory behavior in the open field and in the elevated plus maze, both indicative of anxiety. Phox2b(+/-) mice did not show cognitive or motor impairments. PMID: 25582512
    5. many cranial nerve-associated crest cells coexpress the pan-autonomic determinant Paired-like homeodomain 2b (Phox2b) together with markers of Schwann cell precursors. Some give rise to Schwann cells after down-regulation of PHOX2b. PMID: 24925912
    6. In this review, conditional mouse mutants of Phox2b(27Ala) lacked the ventilary response to hypercapnia at birth. PMID: 23692929
    7. Phox2b transcripts were identified in FAC-sorted Pitx3 positive neurons. PMID: 23251691
    8. This study demonistrated that Phox2b-expressing retrotrapezoid neurons are intrinsically responsive to H+ and CO2. PMID: 23637167
    9. Nonpolyalanine repeat expansion mutation of PHOX2B is both a dominant-negative and gain-of-function mutation. PMID: 22922260
    10. The PHOX2B can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching. PMID: 21624811
    11. The cranial sensory pathways, somatic and visceral, are related, and Phox2b serves as a developmental switch from the former to the latter. PMID: 22128334
    12. Phox2b mutants lack a retrotrapezoid nucleus and their breathing is not stimulated by elevated CO(2) PMID: 21900566
    13. the interaction of bHLH transcription factor Hand2 with E2a is required for transcription of Phox2b, which is essential for autonomic nervous system neuron development. PMID: 21453680
    14. Phox2b-variants (wt and neuroblastoma related) affect proliferation of cultured sympathetic precursors. Phox2b variants directly interact with the bHLH transcription factor Hand2. PMID: 200898
    15. Maintenance of noradrenergic differentiation during embryogenesis requires ongoing expression of Phox2b in sympathetic ganglia, and of Phox2a in the main noradrenergic center, the locus coeruleus. PMID: 21068058
    16. Inner ear efferent neurons depend on Phox2b for their differentiation. PMID: 12885554
    17. Phox2b heterozygous mutants have an altered response to hypoxia and hypercapnia at birth. PMID: 14627719
    18. In Phox2b heterozygous mutants the ciliary ganglion is highly atrophic. Mice carrying a targeted allele of Phox2b have dilated pupils as constriction of the pupil is mediated by the ciliary ganglion PMID: 15150159
    19. Direct target of Hoxb1 and Hoxb2. Highly conserved Phox2b proximal enhancer mediates rhombomere-restricted expression. PMID: 15289435
    20. Data show that Phox2B regulates very early events in the differentiation of adrenal chromaffin cells. PMID: 15733675
    21. Although respiratory phenotype was much less severe than central congenital hypoventilation syndrome(CCHS), Phox2b(+/-) mutant mice showed sleep-disordered breathing, which partially modeled key feature of CCHS. PMID: 15860752
    22. Phox2 genes have roles in neural differentiation PMID: 16319924
    23. These results support the PHOX2B-TLX2 promoter interaction, suggesting a physiological role in the transcription-factor cascade underlying the differentiation of neuronal lineages of the Autonomic Nervous System during human embryogenesis. PMID: 16402914
    24. The ventillatory decrease caused by hyperoxia was larger and more sustained in mutant Phox2b+/- pups than in their wild-type littermates. PMID: 16410396
    25. ambient temperature strongly influenced the hypercapnic ventilatory response in Phox2b+/- mutant mice PMID: 17715184
    26. show that mice bearing a mutation in Phox2b that causes congenital central hypoventilation syndrome in humans breathe irregularly PMID: 18198276
    27. Data show Phox2b expression in mature enteric glia below that of enteric neurons, and suggest that the wavefront of migrating enteric progenitors is not homogeneous, and these cells may be fate-specified before expression of mature lineage markers. PMID: 18351668
    28. down-regulation of Sfrp1 and Sox13 are essential aspects of the genetic program controlled by Phox2b in cranial motoneurons PMID: 18565209
    29. Heterozygous Phox2b(27Ala/+) pups exhibited a lack of responsiveness to hypercapnia and unstable breathing. PMID: 18675942
    30. We characterized a bilateral embryonic parafacial (e-pF) population of rhythmically bursting neurons at embryonic day (E) 14.5 in mice expressing Phox2b. PMID: 19578380

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 数据库链接：

    KEGG: mmu:18935

    STRING: 10090.ENSMUSP00000012664

    UniGene: Mm.62505