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  4. Recombinant Mouse Placenta-expressed transcript 1 protein (Plet1)

Recombinant Mouse Placenta-expressed transcript 1 protein (Plet1)

In Stock
  • 货号：
    CSB-EP851843MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Plet1; Placenta-expressed transcript 1 protein; Antigen mAgK114
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    36.1kDa
  • 表达区域：
    28-218aa
  • 氨基酸序列
    SDNGSCVVLDNIYTSDILEISTMANVSGGDVTYTVTVPVNDSVSAVILKAVKEDDSPVGTWSGTYEKCNDSSVYYNLTSQSQSVFQTNWTVPTSEDVTKVNLQVLIVVNRTASKSSVKMEQVQPSASTPIPESSETSQTINTTPTVNTAKTTAKDTANTTAVTTANTTANTTAVTTAKTTAKSLAIRTLGS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：
        小鼠胎盘表达转录本1蛋白（Plet1）是一种在胎盘中表达的蛋白质，其在小鼠的滋养层细胞命运决定中具有潜在作用。这种蛋白质的表达可能参与细胞-基质粘附的负调控、细胞迁移的正调控以及伤口愈合，表皮细胞的扩散。在科研方向，Plet1可应用于以下几个方向：
        ① 功能研究，Plet1是一种在胎盘中表达的蛋白质，其在小鼠滋养层细胞的命运决定中发挥了重要作用。科学家们已经开始评估Plet1在调节滋养层细胞身份形成和调控滋养层分化方面的功能。
        ② 组织修复，Plet1还参与了细胞-基质粘附的负调控、细胞迁移的正调控以及伤口愈合过程中表皮细胞的扩散。
        ③ 细胞表面蛋白，Plet1是一种表膜蛋白，它在小鼠和猪的胎盘中表达，并在胚胎外胚层、泌尿生殖系统、肠道、肺等结构中表达。
        ④ 细胞迁移，小肠中的小鼠CD11b+CD103+ DCs表达Plet1，这是一种糖磷脂酰肌醇(GPI)锚定的表面蛋白，参与角质细胞在创伤愈合期间的迁移。
        j9九游会登录入口首页生物提供大肠杆菌表达系统制备的全长小鼠Plet1重组蛋白，具备高纯度、高稳定性等特点，助您进行相关科研工作。
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.
  • 基因功能参考文献：
    1. The endogenous dynamics of Plet1 expression establish important patterning cues within the trophoblast compartment by promoting differentiation towards the syncytiotrophoblast or giant cell pathway in Plet1-low and Plet1-high cells, respectively. PMID: 27121762
    2. these results show that IL-17A-induced PLET1 expression contributes to tissue repair and colon tumorigenesis PMID: 29070673
    3. The restricted localization in both differentiated outer root sheath and companion layer cells contacting the hair fiber and epidermal wounds suggests a role for the Plet-1 protein in regulating the interaction of keratinocytes with inert tissues. PMID: 20130590
    4. Plet-1 will thus provide an invaluable tool for genetic analysis of the lineage relationships and molecular mechanisms operating in the development, homeostasis, and injury in several organ/tissue systems PMID: 18195351
  • 亚细胞定位：
    Apical cell membrane; Lipid-anchor, GPI-anchor. Note=Localized at the apical membrane of the most differentiated keratinocytes of the outer root sheath (ORS), clustered mainly in planar regions of the plasma membrane at the base of microvilli.
  • 组织特异性：
    Present in hair follicle cells and sebaceous gland of skin, ciliated epithelial cells of trachea and bronchial tube, striated portion of submandibular gland, distal convoluted tubule cells of kidney, ciliated epithelial cells of oviduct, medulla of adrena
  • 数据库链接：

    KEGG: mmu:76509

    STRING: 10090.ENSMUSP00000110118

    UniGene: Mm.29959