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  4. Recombinant Mouse Polycomb protein Suz12 (Suz12)

Recombinant Mouse Polycomb protein Suz12 (Suz12)

  • 中文名称：
    小鼠Suz12重组蛋白
  • 货号：
    CSB-YP773903MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Suz12重组蛋白
  • 货号：
    CSB-EP773903MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Suz12重组蛋白
  • 货号：
    CSB-EP773903MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Suz12重组蛋白
  • 货号：
    CSB-BP773903MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Suz12重组蛋白
  • 货号：
    CSB-MP773903MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Suz12
  • Uniprot No.：
  • 别名：
    Suz12; D11Ertd530e; Kiaa0160; Polycomb protein Suz12; Suppressor of zeste 12 protein homolog
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-741
  • 氨基酸序列
    MAPQKHGGGG GGGSGPSAGS GGGGFGGSAA AVAAAASGGK SGGGGCGGGG SYSASSSSAA AAAAAAGAAV LPVKKPKMEH VQADHELFLQ AFEKPTQIYR FLRTRNLIAP IFLHRTLTYM SHRNSRTSIK RKTFKVDDML SKVEKMKGEQ ESHSLSAHLQ LTFTGFFHKN DKPSQNSENE QNSVTLEVLL VKVCHKKRKD VSCPIRQVPT GKKQVPLNPD LNQTKPGNFP SLAVSSNEFE PSNSHMVKSY SLLFRVTRPG RREFNGMING ETNENIDVSE ELPARRKRNR EDGEKTFVAQ MTVFDKNRRL QLLDGEYEVA MQEMEECPIS KKRATWETIL DGKRLPPFET FSQGPTLQFT LRWTGETNDK STAPVAKPLA TRNSESLHQE NKPGSVKPAQ TIAVKETLTT ELQTRKEKDN SNESRQKLRI FYQFLYNNNT RQQTEARDDL HCPWCTLNCR KLYSLLKHLK LCHSRFIFNY VYHPKGARID VSINECYDGS YAGNPQDIHR QPGFAFSRNG PVKRTPITHI LVCRPKRTKA SMSEFLESED GEVEQQRTYS SGHNRLYFHS DTCLPLRPQE MEVDSEDEKD PEWLREKTIT QIEEFSDVNE GEKEVMKLWN LHVMKHGFIA DNQMNHACML FVENYGQKII KKNLCRNFML HLVSMHDFNL ISIMSIDKAV TKLREMQQKL EKGESATPSN EEIAEEQNGT ANGFSETNSK EKALETDGVS GVPKQSKKQK L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8.
  • 基因功能参考文献：
    1. we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes PMID: 27150236
    2. lncRNA OL1 interacts with Suz12-PRC2 complex to orchestrate the oligodendrocyte differentiation program. PMID: 28041882
    3. in the skin epithelium, EED, Suz12, and Ezh1/2 function largely as subunits of the PRC2 complex and have roles in skin development PMID: 26994968
    4. Although Suz12 was required for lymphoid development, deletion in individual blood cell lineages revealed that it was dispensable for the development of granulocytic, monocytic, and megakaryocytic cells. PMID: 26036803
    5. PRC2 is a tumor suppressor in Emicro-myc lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2. PMID: 23982173
    6. PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia. PMID: 22469984
    7. The distinct expression profile of the identified Suz12 repressed genes in combination with the proliferation genes hold promise as biomarkers for progression of chronic Hepatitis B V infection to Hepatocellular Carcinoma. PMID: 22505317
    8. polycomb proteins BMI1 and SUZ12 are required for cell transformation induced by organic arsenic exposure PMID: 22843710
    9. Data indicate that binding of EZH2, SUZ12 and EED, the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin. PMID: 22279536
    10. identify polycomb-like 2 and Polycomb Repressive Complex 2 transcriptional targets and draft regulatory networks.[Polycomb Repressive Complex 2 and polycomb-like 2] PMID: 20144788
    11. Quantitative mass spectrometry was used to investigate the effects of Suz12 deficiency on H3.2 and H3.3 from mouse embryonic stem cells. PMID: 20150217
    12. Here we show that mice lacking Suz12, like Ezh2 and Eed mutant mice, are not viable and die during early postimplantation stages displaying severe developmental and proliferative defects. PMID: 15385962
    13. Data show that Suz12(-/-) mouse embryonic stem cells can be established and expanded in tissue culture, but are impaired in proper differentiation, resulting in a lack of repression of cell markers as well as activation of differentiation-specific genes. PMID: 17339329
    14. SUZ12 regulates H3-K9 methylation in an EZH2-independent fashion. Suz12 is required for histone H3 lysine 9 tri-methylation (H3K9me3) in differentiated but not undifferentiated mouse embryonic stem cells. PMID: 17406994
    15. transcriptional components of the RAR signaling pathway are specifically required for displacement of SUZ12 from RAREs during RA-mediated differentiation of F9 cells PMID: 17875646
    16. Suz12, a component of the polycomb repressor complex 2, is recruited to the beta-globin gene. PMID: 17970752
    17. loss of Suz12 function enhances hematopoietic stem cell (HSC) activity PMID: 18416604
    18. These results demonstrate that Snail1 recruits PRC2 component Suz12 to the CDH1 promoter and requires the activity of this complex to repress E-cadherin expression. PMID: 18519590
    19. Suz12 haploinsufficiency results in diverse malformations of the brain and neural tube PMID: 19535498
    20. Suz12 are significantly downregulated during murine skin repair. PMID: 19575012

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  • 亚细胞定位：
    Nucleus. Chromosome. Note=Localizes to the inactive X chromosome in trophoblast stem cells.
  • 蛋白家族：
    VEFS (VRN2-EMF2-FIS2-SU(Z)12) family
  • 组织特异性：
    Expressed in embryonic stem cells.
  • 数据库链接：

    KEGG: mmu:52615

    STRING: 10090.ENSMUSP00000017692

    UniGene: Mm.283410