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  4. Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4 (Alkbh4)

Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4 (Alkbh4)

  • 中文名称：
    Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4(Alkbh4),Yeast
  • 货号：
    CSB-YP861572MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4(Alkbh4),Yeast
  • 货号：
    CSB-EP861572MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4(Alkbh4),Yeast
  • 货号：
    CSB-EP861572MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4(Alkbh4),Yeast
  • 货号：
    CSB-BP861572MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Probable alpha-ketoglutarate-dependent dioxygenase ABH4(Alkbh4),Yeast
  • 货号：
    CSB-MP861572MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Alkbh4
  • Uniprot No.：
  • 别名：
    Alkbh4Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; Alkylated DNA repair protein alkB homolog 4; DNA N6-methyl adenine demethylase ALKBH4; EC 1.14.11.51; Lysine-specific demethylase ALKBH4; EC 1.14.11.-
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-300
  • 氨基酸序列
    AAAAEVSLL QECGCKGIRT CLICERQRHR DPPWQICLQK KCCFLYCPDT GWAAGAEGSD LEGWAFPFPG VTLIQDFVTP EEEAEMVRLM DCDPWKLSQS GRKKQDYGPK VNFRKQKLKM AGFQGLPGFS QKVVQRMGLY PGLEDFQPVE QCNLDYSPER GSAIDPHLDD AWLWGERLVS LNLLSATVVS MSPEAPGSLL LCSAPSVRPD AFEDSLVAPS RSVPCQEVEV AITVPRRSLL VLTGAARHQW THAIHRRHIK ARRVCATFRE LSSEFLPGGK QQELGQELLQ AALSFQGRPV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing.
  • 基因功能参考文献：
    1. ALKBH4 is essential for the development of spermatocytes during the prophase of meiosis. PMID: 25153837
    2. ALKBH4-dependent actin demethylation regulates actomyosin function by promoting actin-non-muscle myosin II interaction. PMID: 23673617
  • 亚细胞定位：
    Cytoplasm. Nucleus. Nucleus, nucleolus. Midbody.
  • 蛋白家族：
    AlkB family
  • 数据库链接：

    KEGG: mmu:72041

    STRING: 10090.ENSMUSP00000098134

    UniGene: Mm.294725