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  4. Recombinant Mouse Properdin (Cfp)

Recombinant Mouse Properdin (Cfp)

  • 中文名称：
    Recombinant Mouse Properdin(Cfp)
  • 货号：
    CSB-BP005291MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Properdin(Cfp)
  • 货号：
    CSB-EP005291MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Name:Cfp Synonyms:Pfc
  • Uniprot No.：
  • 别名：
    Cfp; Pfc; Properdin; Complement factor P
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-464
  • 氨基酸序列
    SDPVLCFT QYEESSGRCK GLLGRDIRVE DCCLNAAYAF QEHDGGLCQA CRSPQWSAWS LWGPCSVTCS EGSQLRHRRC VGRGGQCSEN VAPGTLEWQL QACEDQPCCP EMGGWSEWGP WGPCSVTCSK GTQIRQRVCD NPAPKCGGHC PGEAQQSQAC DTQKTCPTHG AWASWGPWSP CSGSCLGGAQ EPKETRSRSC SAPAPSHQPP GKPCSGPAYE HKACSGLPPC PVAGGWGPWS PLSPCSVTCG LGQTLEQRTC DHPAPRHGGP FCAGDATRNQ MCNKAVPCPV NGEWEAWGKW SDCSRLRMSI NCEGTPGQQS RSRSCGGRKF NGKPCAGKLQ DIRHCYNIHN CIMKGSWSQW STWSLCTPPC SPNATRVRQR LCTPLLPKYP PTVSMVEGQG EKNVTFWGTP RPLCEALQGQ KLVVEEKRSC LHVPVCKDPE EKKP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
  • 基因功能参考文献：
    1. The results show that Properdin plays a key role in allergen-induced airway inflammation and represents a potential therapeutic target for human asthma. PMID: 26116506
    2. s conclude that properdin controls the strength of immune responses by affecting humoral as well as cellular phenotypes during acute bacterial infection and ensuing inflammation. PMID: 24728387
    3. Properdin deficiency exacerbated renal injury in mice lacking complement factor H. PMID: 23184055
    4. deficiency of properdin in mice with factor H mutation exacerbates C3 glomerulonephritis PMID: 23204401
    5. Murine antigonococcal antiserum required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains. PMID: 22368277
    6. properdin may be added to the list of complement proteins which influence lipid metabolism, energy storage and insulin resistance, and further support the hypothesis of a dual role of complement in adipose tissue PMID: 22387270
    7. At the initial phase of local, zymosan-induced inflammation, properdin-deficient and wild-type mice showed bone erosion, proteoglycan loss and cell infiltration. PMID: 20226532
    8. Properdin localizes to mast cells, has the ability to directly associate with Escherichia coli DH5alpha, and plays a significant role in the outcome of polymicrobial sepsis. PMID: 18292556
    9. properdin deficiency attenuates zymosan-induced shock and exacerbates LPS-induced shock. PMID: 18453618

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: mmu:18636

    STRING: 10090.ENSMUSP00000001156

    UniGene: Mm.3064