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  4. Recombinant Mouse Prostatic acid phosphatase (Acpp)

Recombinant Mouse Prostatic acid phosphatase (Acpp)

  • 中文名称：
    Recombinant Mouse Prostatic acid phosphatase(Acpp),Yeast
  • 货号：
    CSB-YP805570MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Prostatic acid phosphatase(Acpp),Yeast
  • 货号：
    CSB-EP805570MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Prostatic acid phosphatase(Acpp),Yeast
  • 货号：
    CSB-EP805570MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Prostatic acid phosphatase(Acpp),Yeast
  • 货号：
    CSB-BP805570MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Prostatic acid phosphatase(Acpp),Yeast
  • 货号：
    CSB-MP805570MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Acpp
  • Uniprot No.：
  • 别名：
    Acp3; Acpp; Prostatic acid phosphatase; EC 3.1.3.2; 5'-nucleotidase; 5'-NT; EC 3.1.3.5; Acid phosphatase 3; Ecto-5'-nucleotidase; Fluoride-resistant acid phosphatase; FRAP; Thiamine monophosphatase; TMPase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    32-381
  • 氨基酸序列
    KELKFVTLV FRHGDRGPIE TFPTDPITES SWPQGFGQLT QWGMEQHYEL GSYIRKRYGR FLNDTYKHDQ IYIRSTDVDR TLMSAMTNLA ALFPPEGISI WNPRLLWQPI PVHTVSLSED RLLYLPFRDC PRFEELKSET LESEEFLKRL HPYKSFLDTL SSLSGFDDQD LFGIWSKVYD PLFCESVHNF TLPSWATEDA MIKLKELSEL SLLSLYGIHK QKEKSRLQGG VLVNEILKNM KLATQPQKYK KLVMYSAHDT TVSGLQMALD VYNGVLPPYA SCHMMELYHD KGGHFVEMYY RNETQNEPYP LTLPGCTHSC PLEKFAELLD PVISQDWATE CMATSSHQGR N
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.; In addition to its tyrosine phosphatase activity, also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP. This extracellular adenosine leads to a decrease in chronic pain by activating A1R in nociceptive neurons.
  • 基因功能参考文献：
    1. PAP-immunoreactivity was present in type I and one of type III taste cells of taste buds. Thus, it is suggested that PAP might be a responsible ectoenzyme for metabolism of extracellular nucleotides, being involved in the regulation of taste signaling in taste buds. PMID: 27348306
    2. These findings demonstrate that PAP secreted by PCa cells in OB bone metastases increases osteoprotegerin and plays a critical role in the vicious cross talk between cancer and bone cells. PMID: 27783536
    3. functional PAP(thorn) neurons are essential for the analgesic effect, which is mediated by NGF-trkA signaling. PMID: 27306411
    4. TMPAP is involved in the control of GABAergic tone in the brain also through exocytosis, and that PAP deficiency produces a distinct neurological phenotype. PMID: 24846136
    5. In male mouse saliva prostatic acid phosphatase regulates salivation. PMID: 24717577
    6. Data indicate that prostate acid phosphatase-based peptide vaccine PAP-114-128 peptide appears to be a relevant for the treatment of prostate cancer. PMID: 24338683
    7. this PAP-/- mouse model shows that TMPAP is required for the normal function of prostate in mice, and its deficiency leads to prostate adenocarcinoma. PMID: 24039861
    8. Both prostatic acid phosphatase and ecto-5'-nucleotidase generate adenosine in the dorsal spinal cord. PMID: 23825434
    9. Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine. PMID: 23119057
    10. prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth PMID: 20498373
    11. studies highlight similarities and differences in PAP localization within nociceptive neurons of mice and rats PMID: 20084276
    12. PAP has species-conserved antinociceptive effects and has pH-dependent ectonucleotidase activity PMID: 19158948

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  • 亚细胞定位：
    [Isoform 1]: Secreted.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Histidine acid phosphatase family
  • 组织特异性：
    [Isoform 1]: Expressed in salivary gland, thymus and thyroid gland.; [Isoform 2]: Widely expressed in prostate lobes, brain, kidney, liver, lung, muscle, placenta, salivary gland, spleen, thyroid and thymus. Locates to Schwann cells and fibroblasts. Expre
  • 数据库链接：

    KEGG: mmu:56318

    STRING: 10090.ENSMUSP00000059889

    UniGene: Mm.19941