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  4. Recombinant Mouse Protein-arginine deiminase type-6 (Padi6)

Recombinant Mouse Protein-arginine deiminase type-6 (Padi6)

  • 中文名称：
    小鼠Padi6重组蛋白
  • 货号：
    CSB-YP815672MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Padi6重组蛋白
  • 货号：
    CSB-EP815672MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Padi6重组蛋白
  • 货号：
    CSB-EP815672MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Padi6重组蛋白
  • 货号：
    CSB-BP815672MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Padi6重组蛋白
  • 货号：
    CSB-MP815672MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Padi6
  • Uniprot No.：
  • 别名：
    Padi6; Pad6; Padi5; Protein-arginine deiminase type-6; EC 3.5.3.15; Arginine deiminase-like protein; Egg and embryo abundant PAD; ePAD; Peptidylarginine deiminase VI; Protein-arginine deiminase type VI
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-682
  • 氨基酸序列
    MSFQNSLSLS LVNPTHALCM VGMEITLDIS KCAPDKCKSF TIRGSPRILI HISSSVIAGK EDTVVWRSMN HPTVALVRMV APSPTVDEDK VLVSYFCPDQ EVPTATAVLF LTGIEISLEA DIYRDGQLDM PSDKQAKKKW MWGMNGWGAI LLVNCSPNAV GQPDEQSFQE GPREIQNLSQ MNVTVEGPTS ILQNYQLILH TSEEEAKKTR VYWSQRGSSA YELVVGPNKP VYLLPTFENR RKEAFYVEAT EFPSPSFSGL ISLSLSLVEK AHDECIPEIP LYKDTVMFRV APYIFMPSTQ MPLEVYLCRE LQLQGFVDSV TKLSEKSKVQ VVKVYEDPNR QSKWLQDEMA FCYTQAPHKT VSLILDTPRV SKLEDFPMKY TLTPGSGYLI RQTEDHRVAS LDSIGNLMVS PPVKAQGKDY PLGRVLIGGS FYPSSEGRDM NKGLREFVYA QQVQAPVELF SDWLMTGHMD QFMCFVPTND KNNDQKDFRL LLASPSACFE LFEQKQKEGY GNVTLFEDIG AEQLLSNGRE SKTISQILAD KSFREQNTYV EKCISLNRTL LKTELGLEDK DIILIPQLFC LEQLTNVPSN QQSTKLFARP YFPDMLQIIV LGKNLGIPKP FGPKINGTCC LEEKVCGLLE PLGLKCTFID DFDCYLANIG DVCASAIINR VPFAFKWWKM TP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the deimination of arginine residues of proteins. In oocytes, is released during cortical reaction and plays a role in preimplantation cleavage and early embryonic development. May be involved in cytoskeletal reorganization in the egg and early embryo.
  • 基因功能参考文献：
    1. mRNAs, possibly in a complex with MSY2 and PADI6, are bound in the cytoplasmic lattices (CPLs) and may play a role in securing the mRNA-MSY2 complex to the CPLs. PMID: 27929740
    2. Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest PMID: 27545678
    3. PADI6/cytoplasmic lattice superstructure plays a key role in regulating microtubule-mediated organelle positioning and movement. PMID: 21147087
    4. localized to egg cytoplasmic sheets; possible role for ePAD in cytoskeletal reorganization in the egg and early embryo PMID: 12654293
    5. Inactivation of the PAD6 gene in mice leads to female infertility whereas male fertility is not affected. PMID: 17587491
    6. Phosphorylation and/or YWHA binding may serve as a means of intracellular PADI6 regulation. PMID: 18463355
    7. embryonic genome activation (EGA) is defective in Padi6-/- two-cell embryos PMID: 18599511

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, Cortical granule.
  • 蛋白家族：
    Protein arginine deiminase family
  • 组织特异性：
    Expressed at very high levels in oocytes. Weakly expressed in testis. Expressed in primordial, primary, secondary and Graafian follicles, and in immature oocytes, mature eggs and blastocyst (at protein level).
  • 数据库链接：

    KEGG: mmu:242726

    STRING: 10090.ENSMUSP00000044044

    UniGene: Mm.271661