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  4. Recombinant Mouse Protein phosphatase 1 regulatory subunit 14C (Ppp1r14c)

Recombinant Mouse Protein phosphatase 1 regulatory subunit 14C (Ppp1r14c)

  • 中文名称：
    小鼠Ppp1r14c重组蛋白
  • 货号：
    CSB-YP854519MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ppp1r14c重组蛋白
  • 货号：
    CSB-EP854519MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ppp1r14c重组蛋白
  • 货号：
    CSB-EP854519MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ppp1r14c重组蛋白
  • 货号：
    CSB-BP854519MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ppp1r14c重组蛋白
  • 货号：
    CSB-MP854519MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ppp1r14c
  • Uniprot No.：
  • 别名：
    Ppp1r14c; Kepi; Protein phosphatase 1 regulatory subunit 14C; Kinase-enhanced PP1 inhibitor; PKC-potentiated PP1 inhibitory protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-164
  • 氨基酸序列
    SVVTGGGEA AGGGGGGGAR VFFQSPRGGT GGSPGSSSSS GSSREDSAPV TTVAAAGQVQ QQQRRHQQGK VTVKYDRKEL RKRLVLEEWI VEQLGQLYGC EEEEMPDVEI DIDDLLDANS EEERASKLQE ALVDCYKPTE EFIRELLSRI RGMRKLSPPQ KKSV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibitor of the PP1 regulatory subunit PPP1CA.
  • 基因功能参考文献：
    1. the data presented in this manuscript demonstrate a critical function of VPS35 in regulating PTH1R trafficking. This event and VPS35-interaction with PPP1R14C appear to be essential for turning off PTH1R's endosomal signaling, and promoting PTH1R-mediated catabolic response and bone remodeling. PMID: 27333042
    2. regulation by morphine PMID: 11812771
    3. The expression patterns point to possible roles for KEPI in regulating protein dephosphorylation by inhibiting PP1 activities in a number of brain pathways. PMID: 15837133
    4. PPP1R14C gene encodes a PKC-potentiated inhibitory protein, KEPI, for type-1 Ser/Thr protein phosphatase (PP1). KEPI mRNA and protein are enriched in brain, heart and skeletal muscle. PMID: 11812771
  • 亚细胞定位：
    Endomembrane system; Peripheral membrane protein.
  • 蛋白家族：
    PP1 inhibitor family
  • 组织特异性：
    Detected in heart, muscle, spinal cord, hippocampus, hypothalamus, thalamus, midbrain, brain stem, cerebellum, brain cortex and olfactory bulb.
  • 数据库链接：

    KEGG: mmu:76142

    STRING: 10090.ENSMUSP00000045110

    UniGene: Mm.308126