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  4. Recombinant Mouse RAD51-associated protein 1 (Rad51ap1)

Recombinant Mouse RAD51-associated protein 1 (Rad51ap1)

  • 中文名称：
    小鼠Rad51ap1重组蛋白
  • 货号：
    CSB-YP804461MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rad51ap1重组蛋白
  • 货号：
    CSB-EP804461MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rad51ap1重组蛋白
  • 货号：
    CSB-EP804461MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rad51ap1重组蛋白
  • 货号：
    CSB-BP804461MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rad51ap1重组蛋白
  • 货号：
    CSB-MP804461MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rad51ap1
  • Uniprot No.：
  • 别名：
    Rad51ap1; RAD51-associated protein 1; RAB22; RAD51-interacting protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-337
  • 氨基酸序列
    MVRPTRNRKP INYSQFEDSG NDSDDDFISS STPVNKSKTV PKVLKQDKPK PNLKNLQKEE VLPTEPPKKR VALDDKVFQR GLEVALALSV KELPTLTNQV KKSKEKSTDK QGKEKTENTG KPPRVSNCSV ASDDVEDLDK ITEEGDASSV EGERKSPSQA KAPRRRAPSE GSDGSSANDT ESESATGEGS ESDPDFDESK ESDEDFGVRR SKESKKKTVQ KKPAGEKKER KSKPKCEASV TSVDPAPAAI KSGSPSLPQA VGLPSEATRK PAIMCSPSAE SKRPKWVPPA ASGSRNSSSN ALAGTPAKSP SQSLRLGLSR LAPVKRLHPS ATSSQVR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination. Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51. Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation. Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair. WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2. Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination.
  • 基因功能参考文献：
    1. VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages. PMID: 23271971
    2. RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes. PMID: 21307306
  • 亚细胞定位：
    Chromosome. Nucleus. Chromosome, telomere.
  • 组织特异性：
    Most abundantly expressed in testis. Also expressed in spleen, thymus and bone marrow. Not detected in heart, kidney or liver.
  • 数据库链接：

    KEGG: mmu:19362

    STRING: 10090.ENSMUSP00000107841

    UniGene: Mm.204634