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  4. Recombinant Mouse Renin-1 (Ren1)

Recombinant Mouse Renin-1 (Ren1)

  • 中文名称：
    小鼠Ren1重组蛋白
  • 货号：
    CSB-YP356764MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ren1重组蛋白
  • 货号：
    CSB-EP356764MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ren1重组蛋白
  • 货号：
    CSB-EP356764MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ren1重组蛋白
  • 货号：
    CSB-BP356764MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ren1重组蛋白
  • 货号：
    CSB-MP356764MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ren1
  • Uniprot No.：
  • 别名：
    Ren1; Ren; Ren-1; Renin-1; EC 3.4.23.15; Angiotensinogenase; Kidney renin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    72-402
  • 氨基酸序列
    SPVVLTNYL NTQYYGEIGI GTPPQTFKVI FDTGSANLWV PSTKCSRLYL ACGIHSLYES SDSSSYMENG SDFTIHYGSG RVKGFLSQDS VTVGGITVTQ TFGEVTELPL IPFMLAKFDG VLGMGFPAQA VGGVTPVFDH ILSQGVLKEE VFSVYYNRGS HLLGGEVVLG GSDPQHYQGN FHYVSISKTD SWQITMKGVS VGSSTLLCEE GCAVVVDTGS SFISAPTSSL KLIMQALGAK EKRIEEYVVN CSQVPTLPDI SFDLGGRAYT LSSTDYVLQY PNRRDKLCTL ALHAMDIPPP TGPVWVLGAT FIRKFYTEFD RHNNRIGFAL AR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
  • 基因功能参考文献：
    1. This study reveals that the human renin protein is able to complement the mouse Ren1d(-/-) non-granulated defect and suggests that granulopoiesis requires a structural motif that is conserved between the mouse Ren1d and human renin proteins. PMID: 29123029
    2. These observations demonstrate that activation of the renin-angiotensin system (RAS) promotes colitis in a blood pressure independent manner. Angiotensin II appears to drive colonic mucosal inflammation by promoting intestinal epithelial cell apoptosis and mucosal TH17 responses in colitis development. PMID: 27271344
    3. Mice homozygous for the Ren1c gene disruption (Ren1c-/-) display several morphological and physiological abnormalities, including poorly developed renal medulla, papillary atrophy, hydronephrosis, inability to concentrate the urine, polyuria, polydipsia, renal failure, and anemia. PMID: 28533331
    4. renin inhibition with aliskiren leads to improved ischemia-induced neovascularization that is not dependant on blood pressure lowering PMID: 26295797
    5. Calcineurin inhibitors induce production of renin in the collecting ducts that may contribute to decreased renal blood flow and increased VEGF production. PMID: 26502369
    6. AKR1B7 is expressed within the renin cell throughout development and perturbations to homeostasis, and AKR1B7 is regulated by cAMP levels within the renin cell. PMID: 26180185
    7. Characterize hypertension produced by transduction with a renin1-coding adeno-associated virus. PMID: 26108870
    8. Cx40 is a requirement for the pressure control of renin secretion irrespective of the localization of renin secreting cells. PMID: 25241776
    9. Deletion of renin in the vasculature resulted in neonatal mortality that could be rescued with daily injections of saline PMID: 26246508
    10. Cells of renin lineage (CoRL) serve as progenitors for other cells in kidney disease characterized by both glomerular and tubulointerstitial injury. PMID: 26062877
    11. Specific cross-linking of the high affinity immunoglobulin epsilon receptor on the surface of bone marrow-derived mast cells and heart mast cells elicits the release of enzymatically active renin protein. PMID: 24262755
    12. Blood pressure homeostasis is regulated through transcriptional cis elements controlling renin activity. PMID: 24734888
    13. extraglomerular renin lineage cells represent a major source of repopulating cells for reconstitution of the intraglomerular mesangium after injury PMID: 24904091
    14. Data indicate the role of renin in hypertension linked to loss of connexin 40 (Cx40). PMID: 24614215
    15. Renin secretory granules possess integral lysosomal proteins, confirming that they are indeed modified lysosomes PMID: 23635510
    16. Data indicate that in 1-day-old Task3-/- mice, renal renin concentration was lower than in wild-type mice. PMID: 23698720
    17. Overexpression of renin in the kidney collecting duct elevated blood pressure. Results suggest that collecting duct-derived renin has the potential to modulate blood pressure independent of the systemic renin-angiotensin system PMID: 23702969
    18. renin is released by mechanisms similar to compound exocytosis. PMID: 23235568
    19. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. PMID: 23401498
    20. deletion of Vhl shifts the phenotype of juxtaglomerular cells from a renin- to erythropoietin-secreting cell type, presumably in response to HIF-2 accumulation PMID: 23393316
    21. The enhanced expression of bone renin and angiotensin II plays an important role in the pathology of age-related osteoporosis. PMID: 22785482
    22. Data show that COUP-TFII is involved in the control of renin gene expression. PMID: 22645148
    23. the mouse-renin gene is regulated by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex PMID: 22441348
    24. Changes in preglomerular blood pressure may be an important mediator of the influence of salt intake on the number and distribution of renin-producing cells in the kidney. PMID: 22357914
    25. Data suggest that Western diets (i.e., diets high in saturated fat and or salt) down-regulate expression of renin in kidney. PMID: 21499941
    26. It was concluded that both Nr2f2 and Nr2f6 negatively regulate renin promoter activity, but may do so by divergent mechanisms. PMID: 22278040
    27. VAMP2 and VAMP3 are expressed in JG cells, but only VAMP2 is targeted to renin-containing granules and mediates the stimulatory effect of cAMP on renin exocytosis. PMID: 21708949
    28. genetic disruption of beta-adrenergic receptors reduces basal renin expression along the developing preglomerular tree and in adult kidneys PMID: 21389089
    29. Renin-angiotensin-aldosterone system components are upregulated under endothelin blockade. PMID: 20093323
    30. cathepsin B-deficient mice exhibit no differences compared with controls in their ability to generate active renin, and our results do not support CTSB as the processing enzyme in mice PMID: 20164204
    31. Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-beta(2) gene. Renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. PMID: 12381922
    32. Review. Role of the local renin-angiotensin system in cardiac damage, focussing on transgenic animal models. PMID: 12431444
    33. identification of several binding sites within the renin enhancer region that are essential for high level expression of Ren-1 gene PMID: 12591615
    34. renin transcription is regulated by TNFalpha, which is regulatedby NFkappaB PMID: 14563845
    35. aldosterone exerts a direct positive effect on renin gene expression at the cellular level probably by stabilizing renin mRNA. PMID: 14583438
    36. NO independent of its exact source permits the macula densa pathway of renin secretion to function normally. PMID: 15075180
    37. Transgenic rats overexpressing the mouse Ren1 gene developed myocardial hypertrophy independent of calcineurin. PMID: 15322704
    38. Review. Transcription of renin genes is subject to complex developmental and tissue-specific regulation. A sequence highly homologous to the mouse enhancer is also found in the human and rat renin genes. PMID: 15545507
    39. renin is the only enzyme capable of maintaining plasma angiotensins and that renin expression in the kidney is very tightly regulated at the mRNA level. PMID: 15563565
    40. LXR(alpha) and LXR(beta) regulate renin expression in vivo by directly interacting with the renin promoter PMID: 16007255
    41. the renin enhancer is critical for renin gene expression and physiological sequelae, including response to alteration in salt intake PMID: 16895910
    42. Stimulation of renin by furosemide was not affected by mPGES1 deficiency. PMID: 17442791
    43. The renin enhancer located 2.7 kb upstream of the renin gene is critical for replenishment of renin stores and response in renin to a chronic in vivo stimulus PMID: 17846348
    44. This study describes the three-dimensional development of renin expression in mouse kidneys during fetal and postnatal life. PMID: 17898695
    45. Ren1c(-/-) mice are lean, insulin sensitive, and resistant to diet-induced obesity without changes in food intake and physical activity. The lean phenotype is likely due to a higher metabolic rate and gastrointestinal loss of dietary fat. PMID: 18054319
    46. This study showed that the Ren-1c enhancer does not regulate the rate of promoter activity, but rather increases the probability of achieving an active transcriptional state. PMID: 18307722
    47. Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure. PMID: 18579650
    48. expression of the human VDR in mouse juxtaglomerular cells reduced renin expression without affecting calcium or parathyroid hormone status PMID: 19034301
    49. Continuous activation of the brain renin-angiotensin system impairs cognitive function via stimulation of the angiotensin II type 1 receptor with a decrease in cerebral surface blood flow and an increase in oxidative stress. PMID: 19047580
    50. CBP and p300 are essential for renin cell identity and morphological integrity of the kidney. PMID: 19252086

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  • 亚细胞定位：
    Secreted. Membrane.
  • 蛋白家族：
    Peptidase A1 family
  • 组织特异性：
    Kidney.
  • 数据库链接：

    KEGG: mmu:19701

    STRING: 10090.ENSMUSP00000092135

    UniGene: Mm.220955