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  4. Recombinant Mouse Resistin-like alpha (Retnla)

Recombinant Mouse Resistin-like alpha (Retnla)

  • 中文名称：
    小鼠Retnla重组蛋白
  • 货号：
    CSB-YP880616MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Retnla重组蛋白
  • 货号：
    CSB-EP880616MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Retnla重组蛋白
  • 货号：
    CSB-EP880616MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Retnla重组蛋白
  • 货号：
    CSB-BP880616MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Retnla重组蛋白
  • 货号：
    CSB-MP880616MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Retnla
  • Uniprot No.：
  • 别名：
    Cysteine-rich secreted protein A12-gamma; Cysteine-rich secreted protein FIZZ1; FIZZ1; Parasite-induced macrophage novel gene 1 protein; RELMalpha; Resistin like alpha; Resistin-like alpha; RETNA_MOUSE; Retnla
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-111
  • 氨基酸序列
    DETIEII VENKVKELLA NPANYPSTVT KTLSCTSVKT MNRWASCPAG MTATGCACGF ACGSWEIQSG DTCNCLCLLV DWTTARCCQL S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable hormone. Plays a role in pulmonary vascular remodeling.
  • 基因功能参考文献：
    1. Reconstituting RELMalpha in CD301b(+) MNP-depleted animals restored body weight. PMID: 27566941
    2. These data demonstrate that RELMalpha but not RELMbeta significantly impacts the immune response to N. brasiliensis infection by downregulating the Th2 adaptive immune response in the lung. PMID: 26831469
    3. HIMF can induce HIF-1, vascular endothelial growth factor-A, and interleukin-6, which are critical mediators of both hypoxic inflammation and PH pathophysiology. PMID: 26586659
    4. FIZZ1 induction of adipocyte transdifferentiation to myofibroblast might be a key pathogenic mechanism for the accumulation of myofibroblasts in dermal fibrosis PMID: 26261086
    5. The expression of FIZZ1 was significantly elevated in the lungs of ovalbumin-challenged animals compared to controls. PMID: 25655389
    6. Relm-alpha is one important player in the pathway from IL-4Ralpha signaling in macrophages to the induction of lysyl hydroxylase 2 that directs persistent pro-fibrotic collagen cross-links, in fibroblasts. PMID: 26474656
    7. The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice PMID: 25022542
    8. RELMalpha is involved in immune response-induced pulmonary vascular remodeling and the associated increase in inflammation. PMID: 25569618
    9. results indicates that Retnla protects against Th2-mediated inflammation in an experimental mouse model of asthma, suggesting that therapeutic approaches to enhance the production of Retnla could be valuable for preventing allergic lung inflammation PMID: 25415454
    10. s show that in addition to promoting Th17 cytokine responses, RELMalpha inhibits Th2 cytokine expression and Th2-cytokine effector macrophage responses in the Citrobacter rodentium-infected colons. PMID: 24831469
    11. Low FIZZ1 expression is associated with dermal wounds. PMID: 24636235
    12. FIZZ1 exhibited profibrogenic properties essential for bleomycin induced pulmonary fibrosis. PMID: 24516640
    13. Hypoxia-induced mitogenic factor contributes to activation of vascular inflammation at least in part by inducing endothelial cell apoptosis in the lung PMID: 24793164
    14. Murine primary macrophages treated with HDL showed increased gene expression for the M2 markers Arginase-1 (Arg-1) and Fizz-1 PMID: 23991225
    15. RELMalpha may be involved in stem cell proliferation in the lung, without affecting differentiation potential. PMID: 22891677
    16. Show that pulmonary vascular remodeling in mice induced by chronic hypoxia or antigen challenge is associated with marked increases in HIMF expression. PMID: 23289668
    17. Macrophages undergoing interleukin-4 (IL-4)-induced alternative activation in the presence of hemozoin developed a phenotype specifically lacking in Retnla. PMID: 23090958
    18. Resistin-like molecule alpha promotes pathogenic Th17 cell responses and bacterial-induced intestinal inflammation. PMID: 23355735
    19. identify a largely redundant functional role for Relm-alpha in acute experimental models of allergen-associated Th2 immune responses PMID: 22246861
    20. Bone marrow mesenchymal stem cells transplantation improved LPS-induced lung injury independent of hypoxia-induced mitogenic factor PMID: 21477220
    21. FIZZ1 regulates tracheal smooth muscle contraction through impairment of the epithelium and activation of the mitogen-activated protein kinase pathway in muscle PMID: 20413533
    22. IL-4 signaling may play a significant role in Hypoxia-induced mitogenic factor-induced lung inflammation and vascular remodeling. PMID: 20889544
    23. results demonstrate HIMF-dependent recruitment of bone marrow derived mesenchymal-like cells to the remodeling pulmonary vasculature PMID: 20582166
    24. the expression of resistin and RELMalpha are similarly regulated in adipose tissue despite the fact that RELMalpha is exclusively expressed in the stromal vascular fraction of adipose tissue and not in adipocytes PMID: 12145345
    25. RELM-alpha mRNA in white adipose tissue fell by approximately 40% in early lactation; might indicate a role for RELM-alpha in the metabolic adaptations of lactation. PMID: 12163041
    26. inhibits differentiation of preadipocytes into adipocytes; characterization of its oligomeric nature PMID: 12189153
    27. FIZZ1/RELMalpha is a hypoxia-induced mitogenic factor which increased pulmonary arterial pressure and vascular resistance more potently than either endothelin-1 or angiotensin II PMID: 12714564
    28. These results indicate a role for HIMF in lung development, possibly under the control of HIF-2, and suggest that HIMF regulates apoptosis and may participate in lung alveolarization and maturation. PMID: 15117738
    29. Our findings connect HIMF to signaling pathways that regulate inflammation, and thus reveal the critical roles that HIMF plays in lung inflammation. PMID: 16709959
    30. Recombinant HIMF upregulates fetal liver kinase-1 (Flk-1) expression in endothelial cells in a phosphatidylinositol-3 kinase/Akt protein kinase-NF-kappa B signaling pathway-dependent manner, and may play critical roles in pulmonary angiogenesis. PMID: 16872509
    31. These results indicate that hypoxia-induced mitogenic factor (HIMF) enhances angiogenesis by promoting proliferation and migration of endothelial cells via activation of the PI-3K/Akt pathways. PMID: 16982054
    32. Ets-1 is a developmentally expressed transcription factor, which plays important roles in the regulation of HIMF production in the developing lung. PMID: 17127463
    33. HIMF acts as a chemotatic molecule in stimulating the migration of myeloid cells through activation of the Bruton's tyrosine kinase pathway PMID: 17264170
    34. a central proinflammatory role for Relm-alpha in the regulation of colonic inflammation PMID: 19201890
    35. Deficient mice are used as a model of th2 cytokine-dependent lung inflammation. PMID: 19349464
    36. the Th2-inducible gene Retnla suppresses resistance to GI nematode infection, pulmonary granulomatous inflammation, and fibrosis by negatively regulating Th2-dependent responses. PMID: 19381262
    37. mouse HIMF can stimulate intracellular Ca(2+) release in human pulmonary artery smooth muscle cells through the PLC signaling pathway in an IP(3)- and tyrosine phosphorylation-dependent manner PMID: 19429774
    38. Resistin-like alpha negatively regulates Th2 immunity PMID: 19381262
    39. Retnla increases more in Mt1/2-deficient mice than in strain-matched control during acute lung injury PMID: 16166738

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Resistin/FIZZ family
  • 组织特异性：
    Highest levels in adipose tissue.
  • 数据库链接：

    KEGG: mmu:57262

    STRING: 10090.ENSMUSP00000023329

    UniGene: Mm.441868