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  4. Recombinant Mouse Rho-related GTP-binding protein RhoQ (Rhoq)

Recombinant Mouse Rho-related GTP-binding protein RhoQ (Rhoq)

  • 中文名称：
    小鼠Rhoq重组蛋白
  • 货号：
    CSB-YP840299MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Rhoq重组蛋白
  • 货号：
    CSB-EP840299MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Rhoq重组蛋白
  • 货号：
    CSB-EP840299MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Rhoq重组蛋白
  • 货号：
    CSB-BP840299MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Rhoq重组蛋白
  • 货号：
    CSB-MP840299MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rhoq; Arhq; Tc10; Rho-related GTP-binding protein RhoQ; Ras-like protein TC10
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-202
  • 氨基酸序列
    MAHGPGALML KCVVVGDGAV GKTCLLMSYA NDAFPEEYVP TVFDHYAVSV TVGGKQYLLG LYDTAGQEDY DRLRPLSYPM TDVFLICFSV VNPASFQNVK EEWVPELKEY APNVPFLLIG TQIDLRDDPK TLARLNDMKE KPVCVEQGQK LAKEIGACCY VECSALTQKG LKTVFDEAII AILTPKKHTV KKRIGSRCIN CC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.
  • 基因功能参考文献：
    1. this study defines TC10 as an immunomodulatory molecule playing a role in physiological B cell responses PMID: 28747344
    2. activation of TC10 and remodeling of cortical actin, which could occur through the TC10 signaling, are required for osmotic shock-mediated Glut 4 translocation and glucose u PMID: 12215429
    3. structural determinants necessary for TC10 trafficking, localization, and function in adipocytes PMID: 12529401
    4. PKCzeta/lambda can serve as a convergent downstream target for both the PI 3-kinase and TC10 signaling pathways. PMID: 14734537
    5. TC10alpha is specifically required for insulin-stimulated glucose uptake in adipocytes PMID: 17008399
    6. the TC10/GAPEX-5/Rab5 axis mediates insulin-stimulated production of PI(3)P, which regulates trafficking of Glut4 vesicles PMID: 18434594
    7. CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation PMID: 18948252

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  • 亚细胞定位：
    Cytoplasm. Cell membrane; Lipid-anchor.
  • 蛋白家族：
    Small GTPase superfamily, Rho family
  • 数据库链接：

    KEGG: mmu:104215

    STRING: 10090.ENSMUSP00000024956

    UniGene: Mm.826