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  4. Recombinant Mouse SH3 and cysteine-rich domain-containing protein 3 (Stac3)

Recombinant Mouse SH3 and cysteine-rich domain-containing protein 3 (Stac3)

  • 中文名称：
    小鼠Stac3重组蛋白
  • 货号：
    CSB-YP805368MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Stac3重组蛋白
  • 货号：
    CSB-EP805368MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Stac3重组蛋白
  • 货号：
    CSB-EP805368MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Stac3重组蛋白
  • 货号：
    CSB-BP805368MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Stac3重组蛋白
  • 货号：
    CSB-MP805368MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Stac3
  • Uniprot No.：
  • 别名：
    Stac3; SH3 and cysteine-rich domain-containing protein 3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-360
  • 氨基酸序列
    MTEKEVVESP QPPFPGETPQ SGLQRLKQLF KKGSPETAEM EPPPEPQANG EAVGAGGGPI YYIYEEEEEE EEEEEPPPEP PKLVNDKPHK FKDHFFKKPK FCDVCARMIV LNNKFGLRCK NCKTNIHEHC QSYVEMQRCF GKIPPGFRRA YSSPLYSDQQ YAVSAANRND PVFETLRVGV IMANKERKKG QADKKNPLAA MMEEEPESAR PEEGKSQDGN NAEKDKKAEK KTPDDKNKQP GFQQSHYFVA LYRFKALEKD DLDFPPGEKI TVIDDSNEEW WRGKIGEKVG FFPPNFIIRV RAGERVHRVT RSFVGNREIG QITLKKDQIV VQKGDEAGGY VKVYTGRKVG LFPTDFLEEI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane. Slows down the inactivation rate of the calcium channel CACNA1C.
  • 基因功能参考文献：
    1. Thus, the C1 domain of STAC3 is responsible for its stable incorporation into the voltage-sensor (CaV1.1) of excitation-contraction-coupling complex, whereas the SH3 domain containing the Native American myopathy mutation site may be involved in low-affinity functional interactions in excitation-contraction-coupling. PMID: 28112192
    2. These data together confirm a critical role of STAC3 in excitation-contraction coupling but also suggest that STAC3 may have additional functions in skeletal muscle, at least in the hindlimb muscle. PMID: 27184118
    3. Stac3 is directly involved in conformational coupling between CaV1.1 and RyR1. PMID: 27621462
    4. STAC3 is important to myofiber hypertrophy, myofiber-type composition, contraction, and excitation-induced calcium release from the sarcoplasmic reticulum in the postnatal skeletal muscle. PMID: 27073615
    5. Stac3 may play a role in preventing precocious myoblast differentiation during skeletal muscle development PMID: 24788338
    6. Stac3 gene plays a critical role in skeletal muscle development and function in mice. PMID: 23626854
    7. STAC3 mediates voltage-induced Ca2+ release and contractility in skeletal muscles. PMID: 23818578

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  • 亚细胞定位：
    Cytoplasm. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane, sarcolemma, T-tubule.
  • 组织特异性：
    Dected in skeletal muscle, including soleus, extensor digitorum longus, tibialis anterior, quadriceps and gastrocnemius. Detected in tongue.
  • 数据库链接：

    KEGG: mmu:237611

    STRING: 10090.ENSMUSP00000048148

    UniGene: Mm.32087